替米沙坦联合辛伐他汀治疗慢性充血性心力衰竭的疗效

Efficacy of telmisartan combined with simvastatin in patients with congestive heart failure

目的:观察替米沙坦联合辛伐他汀治疗慢性充血性心力衰竭(CHF)的疗效。方法:将132例CHF患者随机分为替米沙坦联合辛伐他汀治疗组(联合治疗组,44例)、辛伐他汀组(44例)和常规对照组(44例)3组,随访180d,观察治疗前后NYHA心功能分级,同时以超声动图检测左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)及E/A来评估治疗效果。结果:联合治疗组疗效优于辛伐他汀组和常规对照组(P<0.05)。辛伐他汀组各指标均优于常规对照组,差异有统计学意义(P<0.05)。LVEF(%)、E/A联合治疗组均优于辛伐他汀组,差异有统计学意义(P<0.05)。结论:替米沙坦联合辛伐他汀治疗CHF比单用辛伐他汀的临床疗效更好。

AIM ： To investigate the clinical therapeutic efficacy of telmisartan combined with simvastatin in patients with congestive heart failure （CHF）. METHODS： A total of 132 patients with CHF were randomly divided into group A （routine treatment group）, group B （simvastatin treatment group） and group C （ telmisartan ＋ simvastatin treatment group）. Tile clinical therapeutic efficacy as well as LVEDD, LVESD, LVEF and E/A were analyzed before and 180 days after treatment. RESULTS： Significant differences were found in the clinical therapeutic efficacy and left ventricular functions among the three groups before treatment and 180 days after treatment （P 〈 0. 05 ）. In group B and group C, left ventricular functions improved more significantly than in group A （P 〈 0. 05 ）. In group C, left ventricular function obviously increased, compared with group B （P 〈 0. 05）. CONCLUSION ： Combined administration of telmisartan and simvastatinv exerts better effects on patients with CHF than a single administration of simvastatin （P 〈 0. 05 ）.