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Ghrelin/obestatin系统与心血管疾病研究进展 被引量：5

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摘要 Ghrelin与多种心血管疾病及其危险因素密切相关,且其异常可能是相关疾病的发病机制之一。Preproghrelin除可产生ghrelin外,还可产生另外一种多肽即obestatin,而且二者的某些生理作用完全相反。Ghrelin/obestatin系统与心血管疾病的关系是一个具有重要意义的研究领域,值得进一步深入研究。本文就这一领域的研究进展进行了综述。
作者 郭志福 郑兴 秦永文
机构地区 第二军医大学长海医院心内科
出处 《心脏杂志》 CAS 2010年第1期123-125,129,共4页 Chinese Heart Journal
基金 国家自然科学基金项目资助(30700380)
关键词 GHRELIN OBESTATIN 心血管疾病 危险因素
分类号 R541 [医药卫生—心血管疾病]
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参考文献23

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同被引文献34

  • 1王锋,刘自刚.血脂、超敏C反应蛋白、D-二聚体、同型半胱氨酸联合检测诊断冠心病的临床意义[J].医学信息（医学与计算机应用）,2014,0(5):75-75. 被引量：6
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  • 3Poykko SM, Kellokoski E, Horkko S, et al. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes, 2003,52:2546-2553.
  • 4Nagaya N, Kojima M, Uematsu M, et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteer. Am J Physiol Regul lntegr Comp Physiol, 2001 , 280 : R 1483 -R 1487.
  • 5Cheunq BM, Li C. Diabetes and hypertension: is there a eommon metabolic pathway? Crow Atheroscler Rep, 2012,14 : 160-166.
  • 6Hwang IS, Ho H, Hoffman BB, et al. Fructose-induced insulin resistance and hypertension in rats. Hypertension, 1987, I 0:512-516.
  • 7Tran LT, Yuen VG, McNeill JH. The fructose-fed rat: a review on the mechanisms of fruetose-induced insulin resistance and hyperten- inn Mnl CI1Rinr, he.m 'flflO ').I4'-l'Q.
  • 8Satou M, Nakamura Y, Ando H, et al. Understanding the funetonal significance of ghrelin processing and degradation. Peptides, 2011,32 : 2183-2190.
  • 9Verhulst PJ, Depoortere 1. Ghrelin' s second life: from appetite stimulate to glucose reguator. World J Gastroenterol, 2012,18 : 3183- 3195.
  • 10Gauna C, Meyler FM, Janssen JA, et al. Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity. J Clin Endocrinol Metab, 2004,89 : 5035-5042.

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心脏杂志
2010年 第1期

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