期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

视黄酸信号与胚胎心脏发育的关系 被引量：2

下载PDF
导出
摘要 视黄酸(RA)是维生素A的代谢产物,在胚胎发育中起着重要的作用,对RA信号的研究已经成为发育生物学研究领域的热点之一。心脏发育过程中,主要包括:心脏原基的出现、心管形成、左右不对称发育、心脏环化、腔室形成、内流系统形成及传导系统发生等阶段。本文从心脏不同发育阶段着手,综述了国内外对RA信号影响心脏发育的最新研究进展,为先天性心脏病的防治提供线索。
作者 龚春华 李军 王大为
机构地区 南京医科大学附属南京儿童医院心内科
出处 《心脏杂志》 CAS 2010年第1期130-132,共3页 Chinese Heart Journal
基金 南京市医学科技发展重点项目资助(ZKX05009) 江苏省科技厅项目资助(BS2005607)
关键词 视黄酸 心脏发育 胚胎
分类号 R977.21 [医药卫生—药品]
  • 相关文献

参考文献11

  • 1Keegan BR, Feldman JL, Begemann G, et al. Hetinoic acid signaling restricts the cardiac: progenitor pool [ J ]. Science, 2005, 307 (5707) :247 - 249.
  • 2Honda M, Hamazaki TS, Komazaki S, et al. RXR agonist enhances the differentiation of cardiomyocytes derived from embryonic stem ceils in serum-free conditions[ J]. Biochem Biophys Res Commun, 2005, 333(4) :1334 - 1340.
  • 3Collop AH, Broomfield JA, Chandraratna RA, el al. Relinoic acid signaling is essential for formation of the heart tube in Xennpus[ J]. Dev Biol, 2006, 291 (1) :96 - 109.
  • 4Li W, Li Y. Regulation of dHAND protein expression by all-trans retinoic acid through ET-1/ETAR signaling in H9c2 cells [J]. J Cell Biochem, 2006, 99(2) :478 -484,.
  • 5张立凤,桂永浩,钟涛,王跃祥,蒋球,崇梅,孙淑娜,宋后燕.视黄酸影响斑马鱼胚胎心脏房室分化[J].复旦学报（医学版）,2007,34(1):88-91. 被引量：7
  • 6Smith TK, Bader DM. Signals from both sides: Control of cardiac development by the endocardium and epicardium [ J ]. Semin Cell Dev Biol, 2007, 18 ( 1 ) :84 - 89.
  • 7Ren X, Li Y, Ma X, et al. Activation of p38/MEF2C pathway by all-trans retinoic acid in cardiac myoblasts[ J]. Life Sci, 2007, 81 (2) :89 -96.
  • 8Palm-Leis A, Singh US, Herbelin 135, et al. Mitogen-activated protein kinases and mitogen-aetivated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes [ J ]. J Biol Chem, 2004, 279 (52) :54905 -54917.
  • 9Yokoyama U, Sato Y, Akaike T, et al. Maternal vitamin A alters gene profiles and structural maturation of the rat ductus arteriosus [J]. Physiol Genomics, 2007, 31 ( 1 ) :139 - 157.
  • 10Cipollnne D, Amati F, Carsetti R, et al. A multiple retinoic acid antagonist induces conotruncal anomalies, including transposition of the great arteries, in mice [ J ]. Cardiovasc Pathol, 2006, 15 (4) : 194 - 202.

二级参考文献10

  • 1张立凤,钟涛,桂永浩.外源性视黄酸对斑马鱼心血管系统发育的影响[J].中国实验动物学报,2006,14(2):84-88. 被引量：7
  • 2Mark M,Chambon P.Functions of RARs and RXRs in vivo:genetic dissection of the retinoid signaling pathway[J].Pure Appl Chem,2003,5:1732
  • 3Berdougo E,Coleman H,Lee DH,et al.Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish[J].Development,2003,130:6129
  • 4Xavier-Neto J,Rosenthal N,Silva FA,et al.Retinoid signaling and cardiac anteroposterior segmentation[J].Genesis,2001,31:97
  • 5Kilner PJ,Yang GZ,Wilkes AJ,et al.Asymmetric redirection of flow through the heart[J].Nature,2000,404:759
  • 6Lopez-Sanchez C,Climent V,Schoenwolf GC,et al.Induction of cardiogenesis by Hensen's node and fibroblast growth factors[J].Cell Tissue Res,2002,309:249
  • 7Bally-Cuif L,Goutel C,Wassef M,et al.Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor[J].Genes Dev,2000,14:1677
  • 8Moss JB,Xavier-Neto J,Shapiro MD,et al.Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart[J].Dev Biol,1998,199:71
  • 9Simoes-Costa MS,Vasconcelos M,Sampaio AC,et al.The evolutionary origin of cardiac chambers[J].Dev Bio,2005,277:15
  • 10Hochgreb T,Linhares VL,Menezes DC,et al.A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field[J].Development,2003,130:5374

共引文献6

同被引文献27

  • 1张燕军,尹俊,李金泉,李长青.内蒙古阿尔巴斯绒山羊毛囊结构及形态发生过程研究[J].中国农业科学,2007,40(5):1017-1023. 被引量：28
  • 2Nelson A M, Zhao W, Gilliland K L, Zaenglein A L, Liu W, ThiboutotD M. Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells. The Journal of Clinical lnvestigation, 2008, 118(4): 1468-1478.
  • 3Shubeita H E, Sambrook J F, McCormick A M. Molecular cloning and analysis of functional cDNA and genomic clones encoding bovine cellular retinoic acid-binding protein. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84(16): 5645-5649.
  • 4Vaezeslami S, Jia X, Vasileiou C, Borhan B, Geiger J H. Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding. Acta Crystallo,raphica Section D: Biological Crystallography, 2008, 64(12): 1228-1239.
  • 5Boylan J F, Gudas L J. Overexpression of the cellular retinoic acid binding protein-I (CRABP- I ) results in a reduction in differentiation- specific gene expression in F9 tertocarcinoma cells. The Journal of Cell Biology, 1991, 112(5): 965-979.
  • 6Georges S, Isabelle T, Dominique C G, Stefano J, Erikssont U, Saurat J H. Expression of CRABP- I and -II in human epidermal cells. Biochemical Journal, 1992, 287:383-389.
  • 7Propping C, M6nig B, Luksch H, Mey J. Distribution of the cellular retinoic acid binding protein CtL,BP- I in the developing chick optic tectum. Brain Research, 2007.1168:21-31.
  • 8Uhrig M, Brechlin P, Jahn O, Ilyazev Y, Weninger A, Busia L, Honamejad K, Otto M, Hartmann T. Upregulation of CRABP 1 in human neuroblastoma cells overproducing the Alzheimer-typical AI 42 reduces their differentiation potential. BMC Medicine, 2008, 6(1): 38-50.
  • 9Tang X H, Vivero M, Gudas L J. Overexpression of CRABP I in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid. Experimental Cell Research, 2008, 314(1): 38-51.
  • 10Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. 13-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell, 2001, 105(4): 533-545.

引证文献2

二级引证文献7

心脏杂志
2010年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部