有氧运动对急性冠脉综合征患者血清黏附分子和C反应蛋白的影响

Effect of aerobic exercise on serum adhesion molecule and C-reactive protein in patients with acute coronary syndrome

目的:探讨有氧运动对急性冠脉综合征(ACS)患者可溶性细胞间黏附分子-1(sICAM-1)、血管细胞黏附分子-1(sVCAM-1)和C反应蛋白(CRP)水平的影响。方法:选取ACS患者70例,将其分为常规治疗组和有氧运动+常规治疗组(加有氧运动组)。另选健康成人为正常对照组。采用酶联免疫吸附法测定各组sICAM-1和sVCAM-1水平,采用免疫浊度法测定CRP浓度。结果:ACS患者循环血中sICAM-1、sVCAM-1和CRP水平明显高于正常对照组(P<0.01),两组治疗1个月后sICAM-1、sVCAM-1和CRP水平均较治疗前均明显下降(P<0.05和P<0.01)。且两组各项指标比较,加有氧运动组降低更显著(P<0.05)。结论:ACS患者血清中sICAM-1、sVCAM-1和CRP水平明显升高,而有氧运动能明显降低ACS患者血中sICAM-1、sVCAM-1和CRP水平。

AIM： To study the effect of aerobic exercise on serum soluble intercellular adhesion molecule-1 （sICAM-1）, soluble vascular cellular adhesion molecule-1 （sVCAM-1） and C-reactive protein （CRP） in patients with acute coronary syndrome （ACS）. METHODS： Seventy patients with ACS were divided into two groups： regular treatment group and regular treatment plus aerobic exercise group. Healthy subjects were chosen as the control group. Levels of sICAM-1 and sVCAM-1 were tested by ELISA and the level of CRP was tested by immune turbidimetry. The results were compared. RESULTS： The levels of sICAM-1, sVCAM-1 and CRP in ACS patients were significantly higher than those in the control group （P 〈0. 01 ）. After treatment, the level of sICAM-1 , sVCAM-1 and CRP decreased （P 〈 0.05 and P 〈 0.01 ） , especially in the treatment plus aerobic exercise group （P 〈 0.05 and P 〈 0. 01 ）. CONCLUSION： The level of slCAM-1, sVCAM-1 and CRP increase in patients with ACS. Aerobic exercise markedly decreases the levels of sICAM-1, sVCAM-1 and CRP.