期刊文献+

P-选择素和白介素-18在冠状动脉粥样斑块中相关表达

Correlative expression of P-selectin and IL-18 in human coronary atherosclerosis plaque
下载PDF
导出
摘要 目的:检测P-选择素(CD62P)和白介素-18(IL-18)在冠状动脉粥样硬化斑块中的表达水平,探讨CD62P和IL-18二者之间的相关性,为临床防治斑块形成和发展提供理论依据。方法:选取65例尸检有粥样硬化的冠状动脉组织蜡块标本,采用免疫组化和图像分析技术检测冠脉中CD62P和IL-18的表达水平。结果:CD62P表达在冠状动脉血管内皮细胞膜上,表达水平增高时,粥样硬化斑块内巨噬细胞增多;IL-18主要表达在巨噬细胞胞浆中,CD62P表达增高时,IL-18表达也增高,二者表达具有相关性,并呈正相关关系(r=0.81,P<0.01)。结论:CD62P和IL-18在冠状动脉粥样硬化斑块中的表达具有相关性并呈正相关关系,提示二者可能在冠状动脉粥样斑块的形成和发展过程中是互相关联的炎症因子。 AIM: To evaluate the expression level and the relationship of P-selectin (CD62P) and interleukin-18 (IL-18) in human coronary atheroselerosis so as to provide theoretical evidence for clinical prevention and treatment of plaques. METHODS: Sixty five autopsy paraffin samples with coronary atheroselerosis were selected. The expression level of CD62P and IL-18 in the plaque of human coronary atheroselerosis was measured by immunohistochemical technique and image processing system. Data were analyzed statistically with SPSS v. 13. 0 software (SPSS, Chicago, IL). RESULTS : CD62P was expressed in vascular endothelial cell membrane. In coronary atherosclerosis plaques, the number of macrophages and the expression level of IL-18 changed consistently with the expression level of CD62P. A positive eol,elation was found between the expression of IL-18 and CD62P in the plaques (r =0.81, P 〈0. 01 ). CONCLUSION: The expression levels of IL-18 and CD62P are correlated in human coronary atherosclerosis plaques.
出处 《心脏杂志》 CAS 2010年第2期220-221,227,共3页 Chinese Heart Journal
关键词 冠状动脉粥样硬化斑块 P-选择素 白介素-1 8 coronary atherosclerosis plaques P-selectin interleukin-18
  • 相关文献

参考文献7

  • 1郭爱桃,石怀银,韦立新,孙璐.人冠状动脉粥样硬化斑块内细胞成分与斑块稳定性的关系[J].第四军医大学学报,2005,26(22):2093-2096. 被引量:11
  • 2Ross R. Atherosclerosis an inflammatory disease [ J]. N Engl J Med, 1999, 340(2) :115 - 120.
  • 3Naruko T, Ueda M, Haze K, et nl. Neutrophil infiltration of culprit lesions in acute coronat'y syndromes [ J]. Circulation, 2002, 106 ( 23 ) : 2894 - 2900.
  • 4Sakai A, Kume N, Nishi E, et al. P-selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits before intimal accumulation of macrophages and T lymphocytes [ J ]. Arterioscler Thromb Vasc Biol, 1997, 17 (2) : 310 -316.
  • 5Tenger C, Sundborger A, Jawien J, et al. IL-18 accelerate themsclerosis accompanied by elevation of IFN-gamma and CXCLI6 expression ndependently of T cells [J]. Arterioscler Thromb Vasc Biol, 2005, 25(4) :791 -796.
  • 6Khew-goodall Y, Wadham C, Stein BN, et al. Stat-6 activation is essential for interleukin4 induction of P-selectin transcription in human umbilical vein endothelial cells [ J ]. Arterioscler Thromb Vasc Biol, 1999, 19(6) :1421 - 1429.
  • 7Mallat Z, Corbaz A, Scoazec A, et al. lnterleukin-18/interleukin- 18 binding protein signaling modulates atherosclerotic lesion development and stability[J]. Circ Res, 2001, 89(7) :41 -45.

二级参考文献10

  • 1Boyle JJ. Macrophage activation in atherosclerosis: Pathogenesis and pharmacology of plaque rupture [J]. Curr Vasc Pharmacol, 2005;3(1):63-74.
  • 2Hennerici MG. The unstable plaque [J]. Cerebrovasc Dis, 2004;17(Suppl 3):17-31.
  • 3Shah PK. Mechanism of plaque vulnerability and rupture [J]. J Am Coll Cardiol, 2003; 41(4 suppl S): S15-S22.
  • 4Kavurma MM, Bhindi R, Lowe HC, et al. Vessel wall apoptosis and atherosclerotic plaque instability [J]. J Thromb Haemost, 2005; 3(3): 465-479.
  • 5Johnson Ad, Berberian PA, Tytell M. Differential distribution of 70-kd heat shock protein in atherosclerosis. Its potential role in arterial SMC survival [J]. Arterioscler Thromb Vasc Biol, 1995; 15(1): 27-36.
  • 6Lee RT, Libby P. The unstable atheroma [J]. Arterioscler Thromb Vasc Biol, 1997; 17: 1859-1867.
  • 7Lindstedt KA, Kovanen PT. Mast cells in vulnerable coronary plaques: potential mechanisms linking mast cell activation to plaque erosion and rupture [J]. Curr Opin Lipidol, 2004;15(5): 567-573.
  • 8韦立新,石怀银,郭爱桃,李向红,游联璧,陈乐真.稳定性、不稳定性心绞痛及急性心肌梗死病人冠状动脉病变的形态学差异[J].中华病理学杂志,1998,27(3):168-170. 被引量:23
  • 9石怀银,韦立新,佘铭鹏,李向红,郭爱桃,游联璧.冠状动脉斑块中炎性细胞和平滑肌细胞的定量及其与斑块稳定性的关系[J].中华病理学杂志,1999,28(4):256-259. 被引量:24
  • 10郭爱桃,韦立新,石怀银,李向红,游联璧.基质金属蛋白酶1与冠状动脉粥样硬化斑块破裂的关系[J].中华病理学杂志,2000,29(4):263-268. 被引量:45

共引文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部