阿托伐他汀对急性自发性脑出血患者血清IL-1β、TNF-α和OX-LDL水平的影响

Effects of atorvastatin on serum levels of IL-1β,TNF-α and OX-LDL in cerebral spontaneous hemorrhage

目的:观察阿托伐他汀对急性脑出血患者血清IL-1β、TNF-α、和OX-LDL血脂的影响,探讨阿托伐他汀对急性脑出血脑保护作用。方法:60例脑出血患者分为4组:急性脑出血血脂正常组(A组)、急性脑出血高血脂组(AH组)、血脂正常急性脑出血阿托伐他汀治疗组(AT组)、高血脂急性脑出血阿托伐他汀治疗组(AHT组)。神经功能缺损程度评分(Neurological deficiency score,NDS)检测临床治疗效果。双抗体夹心ELISA法测定IL-1β、TNF-α和OX-LDL,生物化学法测定血脂。结果:AT组血清IL-1β、TNF-α、OX-LDL浓度和A组比较显著降低(P<0.05),经过阿托伐他汀治疗2、4、6周后IL-1β、TNF-α、OX-LDL浓度值和治疗前比较无明显变化(P>0.05)。AHT组血清IL-1β、TNF-α、OX-LDL浓度和AH组比较显著降低(P<0.01),经过阿托伐他汀治疗4周、6周后IL-1β、TNF-α、OX-LDL浓度值和治疗2周值比较明显降低(P<0.01)。结论:阿托伐他汀能够降低急性脑出血患者血清IL-1β、TNF-α、OX-LDL水平,阿托伐他汀对急性脑出血可以通过抑制炎症反应和氧化应激发挥治疗保护作用。

Objective： To observe the influence of atorvastatin on serum levels of IL-1β、TNF-α, OX-LDL and serum lipid in cerebral spontaneous hemorrhage to study its protection mechanisms for cerebral spontaneous hemorrhage. Methods： Sixty patients with cerebral hemorrhage were divided into normal serum lipid level group with cerebral spontaneous hemorrhage （A）, and higher serum lipid level group with cerebral spontaneous hemorrhage （AH）, normal serum lipid level cerebral spontaneous hemorrhage group with atorvastatin treatment （AT）, and higher serum lipid level cerebral spontaneous hemorrhage group with atorvastatin treatment （AHT）. Neurological deficiency score was examined. IL-1β、TNF-α, and OX-LDL were measured by enzyme linked immunosorbent assay; and serum lipid level was measured by biochemistry. Results： The serum levels of IL-1β、TNF-α ,and OX-LDL in AT group were significantly decreased compared with those of A group（P〈0.05 ）. At 2w, 4w and 6w after treatment, the serum levels of IL-1β、TNF-α, and OX-LDL had no obvious change compared with those before treatment（P〉0.05 ） ; The serum levels of IL-1β、TNF-α , and OX-LDL in AHT group were significantly lower than those in AH group,and compared with those at 2w,all the levels at 4w and 6w were significantly lower（P〈0.01 ）. Conclusion： Atorvastatin can decrease the serum levels of IL-1β、TNF-α , and OX-LDL and may have protecting functions on cerebral spontaneous hemorrhage by restraining inflammation and oxidative stress.