ATO和ATRA联合化疗治疗急性早幼粒细胞白血病效果观察

Effect of arsenious acid and all-trans retinoic acid in combination with chemotherapy on acute promyelocytic leukemia

目的观察亚砷酸(ATO)、全反式维甲酸(ATRA)和化疗联合治疗急性早幼粒细胞白血病(APL)的疗效和副作用。方法对53例初治APL患者分别采用ATO和ATRA联合化疗诱导缓解。结果完全缓解(CR)率为71.6%,部分缓解(PR)率为13.8%。3年复发率为10.5%。结论ATO联合ATRA与化疗治疗APL患者的缓解高,副作用低和复发率低,是临床上治疗急性早幼粒细胞白血病的首选方案。

Objective To observe the effect and side-effect of arsenious acid（ATO） and all-trans retinoic acid（ATRA） in combination with chemotherapy on acute promyelocytic leukemia （APL）. Methods 53 APL patients were treated wth ATO and ATRA combined with chemotherapy for induction remission. Results The complete remission rate was 71.6%, the partial remission rate was 13.8% ,and the 3 year recurrent rate was 10.5%. Conclusion The treatment of APL patients with arsenious acid and all-trans retinoic acid can achieve a high remission rate and low recurrent rate with less side effect. It has become the scheme of first choice for the treatment of APL patients.