地尔硫治疗慢性肺源性心脏病并发快速室上性心律失常80例

Treatment of 80 Cases of Chronic Pulmonary Heart Disease Following Rapid Ventricular Tachycardia by Diltiazem

目的观察地尔硫对慢性肺源性心脏病急性发作期并发快速室上性心律失常的疗效。方法选取慢性肺源性心脏病急性发作期并发快速室上性心律失常患者158例,分成治疗组80例,对照组78例。治疗组给予地尔硫注射液0.25mg·kg-1静脉推注后,以5～15mg.h-1缓慢静脉泵入或口服地尔硫缓释片90mg,qd或bid;对照组给予西地兰0.2～0.4mg.d-1,qd,静脉注入后,口服地高辛0.125～0.250mg.d-1,qd,两组其他治疗相同。结果治疗组在控制心室率及心功能、改善临床症状和体征等方面均优于对照组(P<0.05)。结论地尔硫治疗慢性肺源性心脏病并发快速室上性心律失常疗效显著,具有良好的安全性和耐受性。

Objective To investigate the effect of dihiazem in the treatment of acute outbreak of chronic pulmonary heart disease following rapid ventricular tachycardia. Methods 158 patients with acute outbreak of chronic pulmonary heart disease following rapid ventricular tacbycardia were selected and randomly divided into the treatment group and control group. 80 cases in treatment group were injected intravenously with 0.25 mg ·kg^-1 dihiazem first, then infused at 5 - 15 mg · h^-1 or administered with diltiazem orally to control ventricular velocity. 78 cases in the control group were injected intravenously 0.2 - 0.4 mg· d^-1 with cedilanid, given digoxin 0. 125 -0.250mg · d^-1 orally, and treated later in the same way as the treatment group. Results The vcntricular velocity was well controlled and cardiac function, clinical symptom and signs were significantly improved in the treatment group compared with the control （ P 〈 0.05 ）. Conclusion Dihiazern is efficient in treatment of chronic pulmonary heart disease following rapid ventrieular tachycardia, with favorable safety and tolerability.