摘要
目的比较丙泊酚分别复合芬太尼和瑞芬太尼用于人工流产术的效果。方法行人工流产术的患者90例,随机分为3组,每组30例。利多卡因组(L组)注射利多卡因40mg后30s静脉注射丙泊酚2mg·kg-1;芬太尼组(F组)注射芬太尼1μg·kg-1后2min静脉注射丙泊酚1.5mg·kg-1;瑞芬太尼组(R组)注射瑞芬太尼1μg·kg-1后30s静脉注射丙泊酚1.5mg·kg-1。手术中根据体动情况酌情追加丙泊酚,每次30～50mg。观察3组患者苏醒时间、术毕等待苏醒时间、注射痛、术中体动次数和程度、丙泊酚用量、需追加丙泊酚的例数、术毕镇痛效果、心率(HR)、平均动脉压(MAP)的变化等。结果F组和R组丙泊酚用量少于L组(P<0.01),R组需追加丙泊酚的例数少于F组和L组(P<0.05),F组和R组术毕的等待苏醒时间比L组短(P<0.01),R组的注射痛明显低于F组和L组(P<0.01)。结论人工流产术时,丙泊酚伍用瑞芬太尼的效果更佳。
Objective To compare the therapeutic effects of using propofol combined with fentanyl or remifentanil in painless abortion. Methods 90 pregnant women who selected painless abortion were randomly divided into three groups, 30 in each group. Group L was given with 2% lidocaine 40 mg first, then injected intravenously with propofol 2 mg·kg^-1 30 s later. Group F and group R were separately given with fentanyl μg ·kg^-1 and remifentanil 1 μg· kg^-1 , then injected intravenously with propofol 1.5 mg·kg^-1 after 2 minutes or 30 s, respectively. Propofol was added in accordance with the dynamic response. The recovery time, wake-up time, infusion pain, body movement, dose of propofol, numbers of patient who needed additional propofol, the analgesia effects, HR and MAP at different time during the whole operation were investigated. Results The doses of propofol in group F and group R were less than those in group L（P 〈0.01 ）, there were fewer cases received additional propofol in group R than group F and group L（P 〈0.05 ）, the wake-up time was shorter in group R and group F compared with group L（P 〈 0.01 ）, the scale of infusion pain in group R was much better than that in group F and group L （P 〈 0.01 ）. Conclusion The effect of propofol combined with remifentanil was better than the other two methods in painless abortion.
出处
《医药导报》
CAS
2010年第3期313-316,共4页
Herald of Medicine
