麻玄止咳合剂对COPD缓解期肺功能的影响

The efficiency of MZX in the treatment of the paracmasis of chronic obstructive pulmonary disease

目的：研究我院自制处方中成药麻玄止咳合剂治疗COPD缓解期的临床疗效。方法：选择符合COPE）缓解期诊断的我院病人50例，随机分为麻玄止咳合剂组（25例）和对照组（25例）。治疗30天后，测定患者肺功能中FEV1／FVC、FEV1％预计值的变化。结果：麻玄止咳合剂组患者的FEV1／FVC、FEV1％预计值均较对照组提高，结果有统计学意义（P〈0．05）。结论：麻玄止咳合剂能明显改善COPD缓解期患者的肺功能，临床疗效佳，可在临床中推广应用。

Objective： To investigate the efficiency, safety, and possible mechanisms of maxuan zhike mixture（MZX）in the treatment of the paracmasis of chronic obstructive pulmonary disease（COPD）.Methods： This study was a prospective, randomized-controlled clinical trial. A total of 50 patients with COPD was equally and randomly distributed into the control group（conventional treatment）and the combination group（conventional treatment plus MZX）. The changes of FEV1/FVC and FEV1% before and after treatment, were measured after the one-month treatment. Results： The FEV1/FVC and FEV1% were both significantly increased in the combination group as compared with those in the control group（P〈0.05）. In addition, no severe adverse event was found in the groups. Conclusions： Addition of MZM to the conventional treatment can effectively improve the the patients＇pulmonary function of paracmasis of chronic obstructive pulmonary . The combination of conventional treatment with Chinese herbal medicine MZM is effective and safe for COPD.