中西医结合治疗冠心病不稳定型心绞痛疗效观察

The Curative Effect Observation of Radix Astragali and Flos Carthami Injection Combined with Routine Western Medicine on Unstable Angina Pectoris of Coronary Artery Disease

目的:观察在常规西医治疗的基础上联合运用黄芪、红花注射液治疗冠心病不稳定型心绞痛的临床疗效,并探讨其作用机理。方法:将76例冠心病不稳定型心绞痛患者随机分为两组。对照组36例,采用西医常规治疗;治疗组40例,在西医常规治疗的基础上给予黄芪注射液、红花注射液治疗2个疗程。结果:治疗组显效13例,有效24例,无效3例,总有效率为92.5%(95%C I=79.3%～98.4%);对照组显效3例,有效23例,无效10例,总有效率为72.2%(95%C I=54.8%～85.8%);两组心绞痛综合疗效比较(u=2.718 7,P=0.008 2),差异有统计学意义;心电图变化综合疗效比较(u=2.111 0,P=0.035 1),差异亦有统计学意义。结论:黄芪、红花注射液联合西医常规治疗冠心病不稳定型心绞痛疗效优于单纯西医治疗,其心绞痛疗效收益为OR=0.21(95%C I=0.05～0.84),NNT=5(95%C I=2.69～30.12);其心电图疗效收益为OR=0.43(95%C I=0.17～1.09),NNT=5(95%C I=2.35～56.21)。

Objective： To observe the effects of routine western medicine combined with radix astragali injection and flos carthami injection on unstable angina pectoris of coronary artery disease, and to investigate the action mechanism. Method ： 76 cases with unstable angina pectoris of coronary artery disease were divided into two groups randomly. The cases in control group were treated by routine western medicine, and the ones in treatment group were done by radix astragali injection and flos carthami injection on the basis of routine western medicine. Radix astragali injection 40ml and flos carthami injection 40ml were mixed into 5% glucose Inj or normal saline 250ml to do intervenous drop infusion, once a day. The course of treatment included 2 weeks. Then electrocardiogram and symptomatic relief of angina pectoris were observed. Result： In treatment group 13 cases were excellent, 24 ones effective, 3 ones ineffective, and the total effective rate was 92.5% （95CI =79.3% -98.4% ）. In control group 3 cases were excellent, 23 ones effective, 10 ones ineffective, and the total effective rate was 72.2% （95CI = 54. 8% - 85.8% ）. There was significant statistical difference between the two groups on curative effect （ u = 2.718 7, P = 0.008 2）. And the significant statistical difference also existed in improvement of electrocardiogram （u = 2.111 0, P = 0. 035 1 ）. Conclusion ： Radix astragali injection and flos carthami injection combined with routine western medicine have better effect than western medicine merely on unstable angina pectoris of coronary artery disease. About curative effect, OR =0.21 （95% CI =0.05 -0.84）, NNT =5（95% CI =2.69 - 30.12）. And about electrocardiogram OR = 0.43 （95 % CI = 0. 17 - 1.09 ）, NNT = 5 （95 % CI = 2.35 - 56.21 ）.