替米沙坦与赖诺普利单独治疗原发性高血压病的效果比较

Study of telmisartan and lisinopril on treatment of primary hypertension

目的评价替米沙坦与赖诺普利治疗原发性高血压的疗效及不良反应。方法115例原发性高血压患者随机分为两组,A组(替米坦80～160mg/d)56例,B组(赖诺普利10～20mg/d)59例,疗程均为8周,观察两组治疗前后血压、血脂、肾功能及不良反应等指标。结果与治疗前相比,两组血压均下降,差异有统计学意义(P<0.05);A、B组间比较,血压差异无显著性;两组治疗前后血脂及肾功能无明显变化;A组不良反应少于B组,差异有统计学意义(P<0.05))。结论替米沙坦与赖诺普利单独治疗均能有效降低血压,且替米沙坦较赖诺普利的不良反应发生率低。

Objective To contrast the effect of telmisartan and lisinopril on primary hypertension. Methods 115 patients with primary hypertension were divided into group A （56 patients） and group B （59 patients）. Group A was treated with telmisartan. Group B was treated with lisinopril. Blood pressure, serum total cholesterol, triglyceride, BUN, Cr and adverse effects were observed. Results Compared with that before treatment, the blood pressure of both group A and group B decreased （P〈0.05）. However, there was no difference in blood pressure between group A and group B. There was no difference in serum total cholesterol, triglyceride, BUN and Cr between the two groups. Compared with group B, group A had much lower side effects （P〈0. 05）. Conclusion Both telmisartan and lisinopril sodium can effectively decrease the blood pressure in the patients with primary hypertension. However, telmisartan has much lower side effects than Lisinopril.