胃病康药效学实验

Pharmacodynamics test of Weibinkang granula in rats

目的观察胃病康颗粒对大鼠乙酸烧灼型胃溃疡愈合的促进作用。方法各组动物麻醉后,在胃腹侧壁胃与幽门窦交界处的中央部位注入乙酸,形成化学损伤型胃溃疡模型,于术后第2 d将动物分为5组,每组各10只动物,均采用灌胃给药。模型对照组:灌服等体积蒸馏水;阳性对照组给予胃苏颗粒:1.4 g/kg;其余3组为胃病康大、中、小3个剂量组,剂量分别为16、8、4 g(生药)/kg。按1 ml/100 g体重的体积给药,连续14 d。末次给药后24 h,解剖观察动物,比较各组胃黏膜溃疡直径及溃疡愈合情况。结果胃病康颗粒大、中、小3个剂量组的溃疡直径较模型对照组明显减小(P<0.01),且有明显的剂量效应关系,愈合率在30%～45%之间,胃苏颗粒有类似的作用。结论胃病康颗粒对胃黏膜损伤有一定的保护作用。

Objective To study the facilitative effect of Weibinkang granula on the healing of acetic acid - cautery type gastric ulcer in rats. Methods SD rats were injected acetic acid at the junction center between stomach abdominal wall and pyloric antrum to establish the models of acetic acid - cautery type gastric ulcer after anesthesia. On day 2 after operation,the rats were divided into five groups （n = 10） and all received intragastric administration at 1 ml/100 g body weight for 14 days. In model control group ,the animals were given distilled water of equal volume;in positive control group, the animals were given Weisu granula （1.4 g/kg） ;16,8,4 g of Weibinkang crude drug per kilogram were administered to the animals in Weibinkang high, moderate and low dosage group, respectively. At 24 h after last administration, the animals were dissected to observe the diameters and healing percentages of the gastric ulcers in each group. Results Compared with model control group, the ulcer diameters in high, moderate and low Weibinkang group decreased significantly （ P 〈 0.01 ）, and there was an obvious dose - effect relationship. The healing rate in three Weibinkang granula groups was between 30% and 45% and Weisu granula had the similar effect. Conclusion Weibinkang granula can protect gastric mucosa from the lesion induced by acetic acid.