Evidence for the involvement of ActA in maturation of the Listeria monocytogenes phagosome
Evidence for the involvement of ActA in maturation of the Listeria monocytogenes phagosome
摘要
Dear Editor, Listeria monocytogenes (Lm), a Gram-positive facultative bacterium, is the causative agent of listeriosis, a food-borne disease affecting humans. During infections, Lm enters phagosomes from which it escapes into the cytoplasm. Listeriolysin O (LLO) is essential, and two phospholipases play a role in this process. Actin polymerization provides the propulsive force that moves the bacteria through the cytoplasm and into adjacent cells. It is initiated by the interaction of the N-terminal domain of ActA,
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