摘要
Dear Editor, Identification of Drosophila melanogaster as a model organism for cancer research has facilitated the exploration of human tumor malignancy. In Drosophila, loss- of-function mutations in the neoplastic tumor suppressor genes （nYSGs） lethal（2）giant larvae （lgl）, discs large （dlg） or scribble （scrib） cause a malignant tumor-like phenotype characteristic of disrupted cell polarity and overgrowth in epithelial tissues such as imaginal discs [1 ].
基金
Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Michel S6m6riva （IBDML, France）, Fumio Matsuzaki （RIKEN CDB, Japan）, Michael J Galko （UT MD Anderson Cancer Center, USA）, Enrique Martin-Blanco （Instituto de Biologia Molecular de Barcelona, Spain）, Dirk Bohmann （University of Rochester, USA）, Kyung-Ok Cho （Baylor College of Medicine, USA）, the Bloomington Drosophila Stock Center, NIGFLY （Japan）, and the Developmental Studies Hybridoma Bank for providing fly strains and antibodies. We also thank Wenjuan Xiang and Wentian Gu in ML＇s Lab for the technical assistance.This work was supported by National Natural Science Foundation of China （30470890）, National Basic Research Program of China （2007CB914504, 2007CB947301）, the Shanghai Pujiang Program （05PJ14075） and Shanghai Leading Academic Discipline Project （B205）.
