三氟甲基磺酸锌催化选择性合成2-苄基-4-氯苯酚

Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)_2

在温和条件下,Zn(OTf)2能有效催化氯化苄对对氯苯酚的C-苄基化反应,选择性合成杀菌剂2-苄基-4-氯苯酚(BCP),合成的优化条件为n(对氯苯酚):n(氯化苄)=1.2:1,催化剂Zn(OTf)2对氯化苄摩尔分数为5%,60℃下反应6h,用硝基甲烷为溶剂,氯化苄转化率和产物BCP的产率分别>99%和94%。

C-Benzylation of 4-ehlorophenol （BCP） was selectively perpared via the catalysis of Zn （OTf）2 under mild conditions with an excellent yield. The optimum reaction conditions included that the molar ratio of the reactants （4-chlorophol： benzyl chloride） was 1.2： 1, 5% Zn （OTf）2 （molar ratio）, and 6 h agitation at 60 ℃ in nitromethane. The conversion of 4-chlorophenol and selectivity of BCP were 〉 99% and 94%, respectively under the conditions.