芳香胺和酚溴化的新工艺

A New Process for the Bromination of Aromatic Amines and Phenols

研究了在室温下,N-溴丁二酰亚胺对芳香胺和酚的溴化工艺,在CHCl3、EtOH或EtOH/CHCl3溶剂中,用等摩尔的N-溴丁二酰亚胺可将某些芳香胺和酚(考察了5种反应底物)选择性地一溴化,产率92%～98%,N-溴丁二酰亚胺和反应底物摩尔比为2:1;某些芳香胺和酚被专一地二溴化(考察了5种反应底物),产率90%～97%。反应无须催化剂,投料后室温搅拌,反应条件温和,产品只需过滤洗涤即可纯化,操作简便。

A new process for the Brominations of aromatic amines and phenols was reported. The reactions were carried out at room temperature with CHCl3, EtOH or EtOH/CHCl3 as solvent, selective monobromination of some aromatic amines and phenols occurred （ five substrates were investigated） at a ratio of N-bromosuccinimide to substrate 1 ： 1, the yields were 92% - 98%. Dibromination of some aromatic amines and phenols occur smoothly （five substrates were investigated） , at a ratio of N-bromosuccinimide to substrate 2：1, the yields were 90% - 97%. As a green and environmentally benign method, the Brominations of aromatic amines and phenols could be achieved at room temperature without using catalysts. In addition, the final products could be collected after filtration and washing process.