阻塞性睡眠呼吸暂停综合征患者血清中S100B蛋白和神经元特异性烯醇化酶水平

Obstructive sleep apnea-hypopnea syndrome patients with serum levels of S100B protein and neuron-specifice nolase

目的探讨阻塞性睡眠呼吸暂停综合征(OSAHS)患者血清中S100B蛋白和神经元特异性烯醇化酶(NSE)的水平及临床意义。方法选择经全夜多导睡眠监测后确诊的36例男性OSAHS患者和20例男性健康体检者作为研究对象,所有研究对象均进行了Epworth嗜睡评分量表评分,其中15例OSAHS患者和10例健康对照者进行简明精神病量表评分以评估是否存在神经精神症状。酶联免疫吸附剂法测定血清S100B蛋白和NSE。结果OSAHS组血清S100B蛋白水平高于对照组;OSAHS组与对照组的NSE水平差异无统计学意义;OSAHS组血清S100B蛋白水平与呼吸暂停低通气指数无相关性;OSAHS组简明精神病量表评分较对照组高,血清S100B蛋白水平与简明精神病量表评分呈正相关(r=0.559,P<0.01)。结论血清S100B蛋白水平在一定程度上能够反映OSAHS患者脑损害程度,在脑损害早期检测S100B蛋白有一定的意义。

Objective To investigate the clinical significance of the obstructive sleep apneahypopnea syndrome （OSAHS） patients with serum levels neuron specific enolase （NSE） and S100B protein. Methods 36 male patients with OSAHS, who were evaluated by full-night polysomnography, and 20 male healthy persons as control subjects were studied. Patients and control subjects were evaluated by Epworth sleepiness scale. 15 case patients and 10 case control subjects were evaluated by brief psychiatric rating scale （BPRS） for the presence of neuropsychiatric symptoms. Serum levels of S100B protein and NSE were measured by enzyme linked immunosorbent assay method. Results OSAHS patients＇ serum levels of S100B protein were higher than the levels of the control group. But comparatively, the levels of the OSAHS group and the control group of the NSE were similar, without significant differences. There was no relationship between the degree of S100B proteinoand apnea-hyopnea index. The BPRS of patients was higher than that of the control subjects; the concentrations of S100B protein in serum were positively correlated with BPRS（r=0.559, P 〈 0.01）. Conclusion The levels of S100B protein can reflect the brain injury in patients with OSAHS, and it plays a significant role in early assessment of the brain injury in OSAHS.