尿微量白蛋白检测在早期肾损伤诊断中的应用

Diagnostic value of microalbuminuria in patients with early renal impairment

目的探讨尿微量白蛋白(m-Alb)对原发性高血压(EH)及糖尿病(DM)患者早期肾损害的诊断价值。方法分别选择已确诊的EH患者47例,DM患者53例,正常健康体检者102例,采用免疫透射比浊法,在全自动生化分析仪上进行尿微量白蛋白的测定,并对检测结果进行比较。结果EH及DM患者的尿微量白蛋白的排出量明显高于正常健康者,差异有显著性(P<0.01)。结论尿微量白蛋白的检测是早期发现肾病最敏感、最可靠的指标,定期对EH及DM患者进行尿微量白蛋白的检测,对发现早期肾损伤有重要的诊断价值。

Objective To examine the relationship between microalbuminuria （m-Alb） and early renal impairment in patients with essential hypertension （EH） and diabetes mellitus （DM）.Methods Urine samples from 47 patients with EH,53 patients with DM and 102 healthy controls were examined. Level of m-Alb was detected by immunoturbidimetric assay through autoanalyzer. Results of urine samples from different groups were compared with each other.Results Concentrations of m-Alb in patients with EH or DM were significantly higher than those of healthy controls （P〈0.01）.Conclusion Concentration of m-Alb examination is an useful indicator for early detection of renal impairment,and it should be routinely examined among patients with EH or DM for detection of early renal impairment.