血清尿酸水平与急性脑梗死患者脑血管损害的相关性分析

Relationship between serum concentration of uric acid and cerebrovascular dysfunction in patients with acute cerebral infarction

目的探讨血清尿酸水平与急性脑梗死患者脑血管损害的相关性。方法选取大动脉粥样硬化(LAA)型和小动脉闭塞(SAO)型急性脑梗死住院患者371例,记录临床危险因素、实验室检查指标,进行统计分析。结果男性、高血压病、高三酰甘油(TG)血症、低高密度脂蛋白胆固醇(HDL-C)血症及血糖升高患者血清尿酸水平较高(P<0.05)。与SAO型相比,LAA型脑梗死患者血清尿酸水平较高,而TG及HDL-C水平较低(P<0.05)。Logistic回归分析结果显明,尿酸水平升高和TG水平降低是发生大血管损害的重要危险因素。结论高尿酸血症患者易发生LAA型脑梗死,而高三酰甘油血症患者易发生SAO型脑梗死。

Objective To investigate the relationship between serum concentration of uric acid and cerebrovascular dysfunction in patients with acute cerebral infarction （CI）.Methods 371 patients with acute CI hospitalized in Zengcheng People＇s hospital were recruited. The patients were classified as large-artery atherosclerosis （LAA） or small-artery occlusion （SAO）. The clinical and laboratory data were recorded. The relationship between uric acid serum concentration and cerebrovascular dysfunction in patients with acute CI was analyzed.Results Increased uric acid values were found in men,hypertensives,and patients with hypertriglyceridemia,low high-density lipoprotein cholesterolemia and hyperglycemia （P〈0.05）. Patients with LAA had higher uric acid and lower triglyceride （TG） and high-density lipoprotein cholesterol （HDL-C） serum concentration. Logistic regression analysis showed that higher uric acid and lower TG level were important risk factors for presence of LAA than SAO.Conclusion Patients with hyperuricemia have a tendency to develop cerebral infarction of LAA,whereas hypertriglyceridemia showed tendency to the occurrence of SAO.