HRMRI对绝经后妇女骨质疏松症药物治疗效果的评价

The assessment on the response to the postmenopausal osteoporosis treatment using HRMRI

目的通过MRI测量跟骨骨小梁微结构观察不同绝经后妇女骨质疏松患者的药物疗效。方法选择健康绝经后妇女按照绝经年限进行分组,通过计算OSTA得分及测量跟骨骨密度筛查,测腰椎正位骨密度,确诊为骨质疏松,共选择38例病例分为2组,做右跟骨MRI后开始服用药物治疗,分别于3个月和6个月重新测量跟骨骨密度,并做右侧跟骨MRI。结果所得骨小梁参数中骨小梁平均面积,骨小梁面积/总面积,节点数/总面积,节点至节点连接长度/骨架长,骨小梁总数,骨架长/总面积经治疗后均有不同程度的增长(P<0.05),欧拉数/总面积经治疗后降低(P<0.05)。绝经10年以内组骨小梁平均面积,骨小梁面积/总面积,节点数/总面积,小梁总数,骨架长/总面积增长幅度均高于绝经10年以后组(P<0.05),欧拉数/总面积绝经10内组下降幅度高于绝经10年以后组(P<0.05)。根骨骨密度治疗前后及两组间比较均无统计学意义(P>0.05)。结论HRMRI对绝经后骨质疏松症疗效评价作用要优于骨密度测量,绝经后10年以内妇女治疗效果较绝经10年以后治疗效果要好。

Objective Observe the effects of different post-menopausal women with osteoporosis in patients with drug efficacy by MRI measurement of trabecular bone micro-architecture. Methods Healthy postmenopausal women grouped according to duration of menopause, by ealeulating the OSTA score and bone mineral density screening measurement, measured lumbar spine bone mineral density, diagnosed with osteoporosis, 38 eases were selected and patients were divided into two groups, to do MRI of the right ealeaneus I before taking medication, respectively, 3 months and 6 months re-survey caleaneus bone mineral density, and do the right ealcaneus MRI. Results The trabecular bone parameters of the average area of trabeeular bone, trabecular bone area/total area, number of nodes/total area of the node to node connection length/frame length, the total number of trabecular bone, skeleton length/total area after treatment varying degrees of growth （ P 〈 0.05 ） , Euler number/total area is reduced after treatment （ P 〈 0. 05 ）. Postmenopausal group within 10 years the average area of trabecular bone, trabecular bone area/total area, number of nodes/total area, trabecular number, frame length/total area of the growth rate were higher than 10 years after menopause group （P 〈 0. 05） , Euler number/total area within the group of 10 postmenopausal decline in more than 10 years after the menopause group. Conclusion HRMRI on the efficacy of postmenopausal osteoporosis in the role of evaluation is superior to bone mineral density measurements. Compared with less than 10 years after menopause, the treatment of postmenopausal women in 10 years is better.