雌激素受体相关受体α与骨代谢

Estrogen receptor-related receptor α and bone metabolism

雌激素受体相关受体α(estrogen receptor-related receptorα,ERRα)是最早发现的一种孤儿核受体,是核受体超家族中一员。它与雌激素受体(estrogen receptors,ERs)有着一定的同源性,但尚未发现任何配体。目前研究证明ERRα在骨代谢、能量代谢的调节以及乳腺癌发生中都起到重要作用。本文主要综述ERRα在骨代谢方面的研究进展,特别是在骨组织中对受体介导的雌激素信号途径的参与,以求进一步了解雌激素调控骨改建的机制,以及展望ERRα作为靶点治疗雌激素相关的骨代谢病的前景。

Estrogen receptor-related receptor α （ERRor） is the first orphan nuclear receptor with sequence homology to the estrogen receptors, but it does not bind estrogen. ERRα plays important roles in bone metabolism, energy metabolism and the genesis of breast cancer. Here we review the literature on bone metabolism, especially its impinging on the estrogen pathway, in order to further investigate the accurate mechanism of bone modeling modulating by estrogen, and prospect a potential role of this receptor as a therapeutic target in osteopenic disorders related to estrogen.