脂肪抽吸术对脂源性激素、炎性标志物及胰岛素抵抗的影响

Effect of liposuction on adipokines, inflammatory markers and insulin resistance

目的探讨脂肪抽吸术对脂源性激素、炎性标志物与胰岛素抵抗的影响，并探讨其临床意义。方法对16例接受腹部脂肪抽吸手术患者术前及术后3个月的血清脂联素、抵抗素、c反应蛋白、白细胞介素-6、肿瘤坏死因子-α及胰岛素敏感性进行检测并比较。结果血清脂联素术后[（5．56±1．03）ng／ml]较术前[（6．54±1．27）ng／ml]明显升高（P〈0．05）；抵抗素术后[（6．30±3．25）pg／ml]较术前[（5．18±2．28）pg／ml]明显下降（P〈0．05）；胰岛素敏感性术后（-3．78±0．39）较术前（-3．48±0．32）明显增强（P〈0．05）；TNF—α术后[（0．19±0．02）pg／ml]较术前[（0．23±0．03）pg／ml]明显升高（P〈0．01）；IL-6术后[（0．27±0．04）pg／ml]与术前[（0．31±0．06）pg／ml]比较，差异无统计学意义（P〉0．05）；CRP术后[（8．03±6．01）mg／L]与术前[（7．28±6．21）mg／L]比较，差异无统计学意义（P〉0．05）。结论腹部脂肪抽吸术在去除大量皮下脂肪的同时，对脂源性激素及胰岛素抵抗等也有非常有益的影响。

Objective To study the effect of large-volume liposuction on adipokines,inflammatory markers and insulin resistance and its significance. Methods The levels of serum adiponectin, resistin, IL-6, ANF-α, CRP and insulin sensitivity were measured preand 3 months postoperatively in 16 consecutive patients undergoing liposuction. Results The adiponectin postoperative [ （5.56 ± 1.03） rig/ ml] was significantly higher than the preoperative [ （6.54 ± 1.27 ） ng/ml ] （ P 〈 0. 05 ） ; the resistin postoperative[ （6.30 ± 3.25 ） pg/ml ] is significantly lower than the preoperative [ （5. 18 ± 2.28 ） pg/ml ] （P 〈 0. 05） ; the insulin sensitivity postoperative （ - 3.78 ± 0. 39 ） significantly increased compared to the preoperative（ -3.48 ±0. 32, P 〈0. 05） ; the TNF-α postoperative [ （0. 19 ± 0. 02） pg/ml] significantly increased compared to the preoperative [ （0. 23 ± 0. 03 ） pg/ml, P 〈 0. 01 ） ] ; the postoperative IL-6 [（0.27 ± 0.04） pg/ml] was similar to the preoperative[（0.31 ± 0.06） pg/ml, P 〉0.05]; the posoperative CRP[ （8.03 ± 6. 01 ） mg/L] was not significantly different with the preoperative [ （7.28 ± 6. 21 ） mg/L,P 〉 0. 05 ]. Conclusions Large-volume liposuction has good effect on insulin resistance and adipokines.