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成骨细胞特异因子-2是影响创伤愈合的重要因子 被引量：1

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摘要 成骨细胞特异因子-2（periostin，POSTN）是一种细胞外基质蛋白，被认为是间质细胞的标记物，具有细胞黏附功能，研究表明其通过促进细胞增殖、迁移和血管合成，参与创伤组织的结构和血管重塑过程。我们旨在总结POSTN在创伤愈合方面的研究进展及其在创伤愈合中的可能机制。
作者 刘畅 秦泽莲
机构地区 北京大学第三医院成形外科
出处 《中华整形外科杂志》 CAS CSCD 北大核心 2010年第1期75-78,共4页 Chinese Journal of Plastic Surgery
关键词 创伤愈合 成骨细胞 因子 特异 细胞外基质蛋白 细胞黏附功能 血管重塑 间质细胞
分类号 R64 [医药卫生—外科学]
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参考文献32

  • 1Takeshita S, Kikuno R, Tezuka K, et al. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J, 1993, 294 (1) : 271-278.
  • 2Kruzynska-Frejtag A, Wang J, Maeda M, et al. Periostin is expressed within the developing teeth at the sites of epithelial- mesenchymal interaction. Dev Dyn, 2004, 229(4) : 857-868.
  • 3Litvin J, Zhu S, Norris R, et al. Periostin family of proteins: therapeutic targets for heart disease. Anat Rec A Discov Mol Cell Evol Biol, 2005, 287(2): 1205-1212.
  • 4Horiuchi K, Amizuka N, Takeshita S, et al. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res, 1999. 14(7): 1239-1249.
  • 5Norris RA, Borg TK, Butcher JT, et al. Neonatal and adult cardiovascular pathophysiological remodeling and repair : developmental role of periostin. Ann N Y Acad Sci, 2008, 1123 : 30-40.
  • 6Litvin J, Selim AH, Montgomery MO, et al. Expression and function of periostin-isoforms in bone. J Cell Biochem, 2004, 92 (5) : 1044-1.061.
  • 7Nakazawa T, Nakajima A, Scki N, et al. Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis. J Orthop Res, 2004, 22 (3) : 520-525.
  • 8Suzuki H, Amizuka N, Kii I, et al. Immunohistoehemical localization of periostin in tooth and its surrounding tissues in mouse mandibles during development. Anat Rec A Discov Mol Cell Evol Biol, 2004, 281(2): 1264-1275.
  • 9Wilde J, Yokozeki M, Terai K, et al. The divergent expression of periostin mRNA in the periodontal ligament during experimental tooth movement. CeU Tissue Res, 2003, 312 (3) : 345-351.
  • 10Oku E, Kanaji T, Takata Y, et al. Periostin and bone marrow fibrosis. Int J Hematol, 2008, 88(1) : 57-63.

二级参考文献41

  • 1王齐,聂芳菲,赵霞,秦泽莲.periostin在过度增生性瘢痕的表达及其与TGF-β1和受体的相关性[J].中华整形外科杂志,2007,23(3):229-232. 被引量：21
  • 2陕声国 张端莲 候祚琼.瘢痕疙瘩成纤维细胞的增殖和凋亡状态[J].中华皮肤科杂志,2000,33(4):280-280.
  • 3Lindner V, Wang Q, Conley BA, et al. Vascular injury induces expression of periostin: implications for vascular cell differentiation and migration. Arterioscler Thromb Vasc Biol, 2005, 25:77-83.
  • 4Horiuchi K, Amizuka N, Takeshita S, et al. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor β. J Bone Miner Res, 1999, 14:1239-1249.
  • 5Takeshita S, Kikuno R, Tezuka K, et al. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J, 1993, 294:271-278.
  • 6Tai IT, Dai M, Chen LB. Pefiostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies. Carcinogenesis, 2005, 26:908-915.
  • 7Shao R, Bao S, Bai X, et al. Acquired expression of pefiostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Molecular and Cellular Biology, 2004, 24:3992-4003.
  • 8Ginan L, Matei D, Fishman DA, et al. Periostin secreted by epithelial ovarian carcinoma is a ligand for avβ3 and avβ5 integrins and promotes cell motility. Cancer Research, 2002, 15:5358-5364.
  • 9Bao S, Ouyang G, Bai X, et al. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 2004, 5:329-339.
  • 10Li P, Oparil S, Feng W, et al. Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells. J Appl Physiol, 2004, 97:1550-1558.

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中华整形外科杂志
2010年 第1期

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