Id_1与Id_3在非小细胞肺癌中的表达及临床意义

The expression and the clinical significance of Id_1 and Id_3 in human non-small cell lung cancer

目的:探索分化抑制因子(Inhibitors of differentiation,Id)Id_1和Id_3在非小细胞肺癌(Non-small cell lung cancer,NSCLC)中的表达及临床意义。方法:采用免疫组化S-P法检测60例NSCLC、8例炎性假瘤、10例肺结核、12例正常肺组织中Id_1和Id_3的表达情况。结果:在人NSCLC组织中,Id_1和Id_3均过度表达,与正常肺组织及良性病变组织(结核和炎性假瘤)比较差异具有显著性(P<0.01);在不同年龄、性别及病理类型中表达的差异无统计学意义(P>0.05);在肿瘤有淋巴结转移组中表达的明显高于无淋巴结转移组,统计分析差异具有显著性(P<0.05)。结论:Id_1、Id_3蛋白与NSCLC的发生发展及淋巴结转移有关,可能作为NSCLC诊断及判断预后的重要标志物。

Objective： To study the expression of Id1 and Id3 in human non-small cell lung cancer （NSCLC）, and to analyze its potential clinical significance. Methods： Id1 and Id3 were detected by immunohistochemieal staining technique in paraffineembedded specimens of 60 NSCLC cases, 18 benign disease cases including 10 tuberculosis and 8 inflammatory pseudotumor （IPT）, and 12 normal lung cases,and analyzed by the lung cancer clinicopathologic characteristics. Results： There were no Id1 or Id3 expression in normal lung tissue,and negative to weak expression of those in benign disease tissues. In contrast, the expression of Id1 and Id3 was obviously upregulated in NSCLC ,which was significantly higher than that in benign disease （P〈0.01）. Furthermore, the over expression of Id1 and Id3 was significantly correlated with lymph node metastasis and was not correlated with pathological type, the different age or the different gender of the patients. Conclusion： In NSCLC, Id1 and Id3 protein are overexpressed and their expression are positive correlated with lymph node metastasis. It suggested that Id1 and Id3 are associated with tumorigenesis, invasion and metastasis in NSCLC. Idl and Ida might be used as new markers of NSCLC for diagnosis and prognosis.