代谢综合征患者颈动脉内-中膜厚度及大动脉弹性的变化

Changes of carotid artery intima-media thickness and elastic artery in patients with metabolic syndrome

目的了解代谢综合征(MS)患者颈动脉内-中膜厚度(IMT)和大动脉弹性的改变及二者间的关系,探讨影响IMT及大动脉弹性的危险因素。方法共选择90例研究对象,其中正常对照组、MS组、MS合并高血压组各30例,分别测定每位研究对象的IMT及脉搏波传导速度(PWV),并测定可能影响二者的危险因素,所有数据采用SPSS11.5进行统计分析。结果代谢综合征患者IMT与PWV均高于正常对照组,且二者呈正相关(r=0.753,P<0.001);影响IMT的主要因素为年龄、收缩压、吸烟;影响PWV的主要因素为年龄、收缩压。结论MS患者IMT与大动脉弹性均发生明显变化,且二者呈同向变化,即IMT增厚时,PWV也增快。影响IMT及大动脉弹性的危险因素主要有年龄、收缩压及吸烟。

Objective To understand changes of carotid artery intima - media thickness （IMT） and elastic artery in patients with metabolic syndrome （MS） ; and to understand the factors that affect IMT and elastic artery. Methods 90 subjects were enrolled in the study and including 30 healthy subjects （the first group）, 30 objects with metabolic syndrome（ the second group ）, 30object with hypertension and metabolic syndrome. By measuring IMT, pulse wave velocity （PWV） and factors which affected them. All data will be used for statistical analysis. Results IMT and PWV of patients with MS and MS ＋ hypertension both higher than those in health group. There was a positive correlation between IMT and PWV （ r = 0. 753 ,P 〈 0. 001 ） ; The main risk factors of IMT were age, SBP and smoking;Conclusion IMT and PWV are changed in patients with MS. When IMT thickness increased, PWV increased faster.