难溶性药物的制剂增溶技术及应用

Solubilizing techniques and their applications to water-insoluble drug preparations

目的:综述难溶性药物增溶和提高生物利用度的制剂技术及应用。方法:查阅国内外相关文献进行总结、归纳。结果:难溶性药物随着制剂技术的改进及新剂型的应用,可通过环糊精包合或复合、固体分散体、微粉化、加增溶剂或助溶剂、成盐处理等多种途径来提高药物的溶出速率和生物利用度。结论:随着药学领域中新制剂技术的发展、新材料的应用,难溶性药物的吸收差、生物利用度低这一限制已逐渐被克服,难溶性药物也可获得较好的吸收和生物利用度。

Objective ： To review the sloubilizing and bioavailability - enhancing techniques and their applications to the water - insoluble drugs. Methods ： Related literature was retrieved and analyzed. Results ： The means which can improve the in - vitro solubility and the bioavailability of water - insoluble drugs include： cyclodextrin inclusion or complex, solid dispersion, mieronization, solubilizer adding, salt forming, et al. Conclusions： With the development of the novel preparation technology and the applications of new materials, the water - insoluble drugs could be administrated with large dissolution rate and high bioavailability.