摘要
目的探讨新型镇痛药帕瑞昔布钠对腹腔镜胆囊切除术患者术后镇痛的效果.方法择期腹腔镜胆囊切除术患者150例,随机分为A组(n=50)帕瑞昔布钠40mg静注;B组(n=50)氯诺昔康16mg静注;C组(n=50)生理盐水5mL静注,A、B和C组均在手术结束前20min给药.用视觉模拟评分法(VAS评分)分别对三组术后1、3、6、12h进行疼痛评分,并记录胃肠道反应、下床活动、精神状况及患者满意程度.结果术后12h内A组(VAS评分≤3分),较B组(VAS评分≤3分)差异无统计学意义(P>0.05),较C组(VAS≥4分)差异有统计学义(P<0.01).A组和B组患者更早地下床活动,精神状况佳,满意率均达90%以上,三组胃肠道副反应无明显差异(P>0.05).结论腹腔镜胆囊切除术中单次用帕瑞昔布纳40mg具有良好的术后镇痛效果,且不增加胃肠道副作用.
Objective To assess the analgesic effect of Parecoxib Na within 12 hours postoperatively in patients undergoing laparoscopic cholecystectomy （LC）. Methods 150 patients undergoing LC were randomly divided into three groups： group A （ n = 50） received Parecoxib Na 40 mg; group B （ n = 50） receiving Lornoxicam 16 mg and group C receiving Physiological saline 5ml .Parecoxib Na, Lornoxicam and Physiological saline were used when the procedure was finished before 20 minutes. The effect of analgesia was assessed by visual analog scale （VAS） within 1, 3, 6, 12 hours postoperatively. Results VAS of group A and group B was lower （≤ 3） than group C （≥4） （P〈0.01）. It showed that Parecoxib Na can reduce pain obviously. Conclusion Parecoxib Na 40 mg has good postoperative analgesic effect in patients undergoing laparoscopic cholecystectomy.
出处
《昆明医学院学报》
2010年第1期62-64,共3页
Journal of Kunming Medical College
关键词
非甾体类抗炎镇痛药
帕瑞昔布钠
氯诺昔康
腹腔镜胆囊切除术
术后镇痛
Nonsteriodal anti-inflammatory drugs
Parecoxib Na
Lornoxicam
Laparoscopic cholecystectomy
Postoperative analgesia
