摘要
目的探讨防哮颗粒对哮喘缓解期气道炎性损伤的防治机制。方法在山东中医药大学药理学实验室制作哮喘缓解期大鼠模型,观察防哮颗粒浓缩液灌胃后对模型大鼠血清白细胞介素4、血液中嗜酸性粒细胞和IgE的影响,并与中药对照组(固本咳喘片)、西药对照组(酮替芬)比较。结果防哮颗粒能降低哮喘缓解期模型大鼠血清中嗜酸性粒细胞、炎性因子白细胞介素4和免疫因子IgE的水平,且与阳性对照组比较差异有统计学意义(P<0.05)。结论防哮颗粒可抑制模型大鼠气道炎症,降低气道高反应,故对哮喘缓解期模型大鼠气道炎性损伤具有良好的预防作用。
Objective To discuss the mechanism of anti-asthma particles on preventing inflammatory airway damage in asthma remission stage. Methods Produce rat model of asthma in remission stage to observe the impact of the anti-asthma particles concentrate on the serum IL-4, EOS, and IgE of the model after gastric perfusion. Compare it with Guben Kechuan Tablets and ketotifen positive controlled groups. Results Anti-asthma particles could reduce levels of serum EOS,inflammatory cytokines IL-4 and immune factors IgE in model rats with asthma in remission stage,and had statistically meaning compared with the positive controlled groups（P〈0. 05）. Conclusions Anti-asthma particles can inhibit airway inflammation and reduce airway hyper-responsiveness in the model rats,so it has good preventive effect on inflammatory airway damage in model rats with asthma in remission stage.
出处
《中国中西医结合儿科学》
2010年第1期49-51,共3页
Chinese Pediatrics of Integrated Traditional and Western Medicine
