高压氧疗早期干预进展性脑梗死的临床疗效

Clinical study of hyperbaric oxygen treatment of acute progressive cerebral infarction

目的回顾性分析高压氧治疗急性进展性脑梗死的临床疗效。方法选择本院神经内、外科住院的63例急性进展性脑梗死患者，完全随机分为对照组30例，高压氧治疗组33例。2组常规治疗措施包括抗凝、扩血管、营养脑神经细胞等，高压氧治疗组在常规治疗基础上早期给予高压氧治疗，10d为一疗程；对2组进行临床治疗效果评价，统计分析神经功能缺损评分较对照组并进行对比。结果高压氧治疗组神经功能缺损评分较对照组改善显著[治疗后21d为（6．32±2．63）VS（11．43±6．78）]，与对照组相比，差异有统计学意义（P〈0．01）。2组临床效果比较，高压氧治疗组显效率高于对照组（71．1％VS50．6％，P〈0．05）o结论高压氧干预进展性脑梗死是一种行之有效的方法，且没有严格受限治疗时间窗的影响，安全性高、副作用小，早期治疗为好。

Objective To explore the therapeutic effects and safety of Hyperbaric Oxygen treating Hyperbaric oxygen （HBO） with acute progressive cerebral infarction （APCI）. Methods Sixty-three patients were randomly divided into two groups. The control group （ n = 30） was treated with conventional therapy for APCI, and the treatment group （n = 33 ） was treated with Hyperbaric Oxygen treatment, combined with conventional therapy for A- cute progressive cerebral infarction （ACI） for two weeks. Results After therapy, the scores of Nervous Functional Deficiency were lower than that observed before therapy, especially in the treatment group （ 6.32±2.63 ） vs （ 11. 43 ±6.78）P〈0.01;71.1% vs 50.6% ,P〈0.05）. Conclusions Hyperbaric oxygen treatment is safe and effec- tive method for patients with acute progressive cerebral infarction.