摘要
近年来,在世界范围内乳腺癌的发病率呈逐年升高的趋势,骨桥蛋白(osteopontin,OPN)是一种分泌型、黏附性的糖基化磷蛋白。近年来的研究揭示,OPN在肿瘤细胞的黏附、移行、浸润、血管新生、凋亡以及肿瘤的微环境中起关键作用,现将其与乳腺癌的关系综述如下。
出处
《中国基层医药》
CAS
2010年第2期268-269,共2页
Chinese Journal of Primary Medicine and Pharmacy
参考文献13
-
1Rittling SR, Chambers AF. Role of osteopontin in tumor progression. Br J Cancer,2004,90(10) :1877-1881.
-
2Prince CW, Oosawa T, Buller WT, et al. Isolation, characterization, and biosynthesis of a phosphorylated glyco protein from rat bone. J Biol Chem, 1987,262 (6) :2900-2907.
-
3Wai PY, Kuo PC. The role of osteopontinin tumor metastasis. J Surg Res ,2004,121 (2) :228-241.
-
4Weber GF. The metastasis gene osleopontin :a candidate target for Cancer therapy. Biochim Biophys Acta,2001 , 155 (2) :61-85.
-
5Denhardt DT, Giachelli CM, Rittling SR, et al. Role of osteopontin in cellular signaliug and toxicant injury. Annu Rev Pharmacol Toxicol,2001,41 ( 2 ) :723-749.
-
6Wang D, Yamamoto S, Hijiya N, et al. Transcrional regulation of the haman osteopontin promoter: functional analysis and DNA- protein interaction . Oncologe ,2000,19 ( 50 ) :5801-5809.
-
7Xie Y, Sakalsume M, Nishial, expression, roles, receptors, andregulation Of osteopontin in the kidney, kidney Int,2001,60 (5) : 1645-1657.
-
8Zhang J ,Takahashi K,Takahashi F,et al. Differential osteopontin expression in lung cancer. Cancer lett ,2001,171 (2) :215-222.
-
9Furger KA, Allan AL, Oates SM, et al. Betaintegrin expression increase breast carcinoma cell responsiveness to the malignancy-enhancing effcets of osteopontin. Mol cancer Ros,2003,1 ( 3 ) : 810- 819.
-
10Gotoh M, Sakamoto M, Kanetaka K, et al. Overexpression of osteopontin in hepato cellular carcinoma. Pathol Int, 2002,52 ( 4 ) : 19-24.
同被引文献7
-
1叶春华,程志清.心肌纤维化与病毒性心肌炎[J].浙江中医学院学报,2004,28(4):85-87. 被引量:5
-
2Collins AR, Schnee J, Wang W, et al. Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart [ J]. J Am Coil Cardiol,2004,43 (9) : 1698-1705.
-
3Rollo EE,Hempson SJ, Bansal A, et al. The cytokine osteopontin modulates the severity of rotavirus diarrhea [ J]. J Virol,2005,79 (6) :3509-3516.
-
4Khan SA, Lopez-Chua CA, Zhang J, et al. Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors [ J ]. J Cell Biochem, 2002,85 (4) : 728-736.
-
5Zohar R,Zhu B, Liu P, et al. Increased cell death in osteopontin- deficient cardiac fibroblasts occurs by a caspase-3-independent pathway [J]. Am J Physiol Heart Circ Physiol,2004,287 (4): H1730-1739.
-
6刘立新,王宇玫,申卫东,丁秀云,王士雯.骨桥蛋白在牛主动脉平滑肌细胞体外钙化时的表达变化[J].解放军医学杂志,2009,34(4):488-489. 被引量:1
-
7杨莉,魏玲,左文述.骨桥蛋白与乳腺癌的研究现状[J].中华肿瘤防治杂志,2011,18(14):1133-1137. 被引量:9
-
1杨宇明,付生,李德祥.p53、bcl-2、bax和p27基因与甲状腺肿瘤细胞凋亡[J].中国煤炭工业医学杂志,2003,6(5):389-391. 被引量:2
-
2郭建光,张玲慧,张连生.三阴乳腺癌生物学特征与预后的关系[J].现代中西医结合杂志,2011,20(26):3364-3365. 被引量:3
-
3黄建,陈衡.PTEN和FHIT基因与卵巢癌关系的研究进展[J].社区医学杂志,2009,7(15):44-46.
-
4刘玉琴,高英敏.FHIT基因与子宫内膜癌[J].兰州医学院学报,2004,30(4):96-98.
-
5王永晨,谭岩.Fas/FasL与恶性黑色素瘤的关系[J].北京医学,2008,30(2):106-110.
-
6叶文静,邢卫斌,秦兰英,付国俊.Survivin与皮肤肿瘤[J].中国美容医学,2012,21(09X):71-72.
-
7胡俊毅,刘瑞,经纬.胰腺癌组织中骨桥蛋白与血管内皮生长因子的表达及其临床意义[J].中华消化杂志,2009,29(1):54-55. 被引量:1
-
8李伟,高勇义,吴智勇,李娥卿.老年2型糖尿病患者外周血单个核细胞对培养的血管内皮黏附性的影响[J].中华老年医学杂志,2004,23(12):859-860. 被引量:1
-
9李伟,黄海英,高勇义,吴智勇,李娥卿.治疗前后2型糖尿病患者外周血单个核细胞对血管内皮黏附性比较[J].中华内科杂志,2004,43(5):374-375.
-
10肿瘤学[J].中国学术期刊文摘,2009,15(1):10-10.