132例白癜风患者自身抗体的检测分析

Analysis of autoantibody levels in 132 vitiligo patients

目的通过分析白癜风患者血清中相关自身抗体的水平,以探讨自身免疫在白癜风患者发病中的作用及其临床意义。方法分别用电化学发光免疫分析法、间接免疫荧光法、乳胶凝集法检测132例白癜风患者与50名正常对照组血清中甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、抗核抗体(ANA)和类风湿因子(RF)的水平,比较白癜风患者与正常对照组间各种自身抗体的阳性率。结果白癜风患者TPO、TGAb及RF阳性率高于正常对照组,两组相比差异有统计学意义(P<0.05),而ANA阳性率两组相比差异无统计学意义(P>0.05)。结论白癜风患者部分自身抗体水平明显高于正常人群,自身免疫与白癜风的发病密切相关,对白癜风患者进行相关自身抗体的检测将有助于预测某些自身免疫性疾病的发生。

Objective To identify the role of autoimmune in the pathogenesis of vitiligo by measurement of the serum autoantibody levels in 132 patients with vitiligo. Methods Thyroid peroxidase antibody （TPOAb）, thyroglobulin antibody （TGab）, antinuclear antibody （ANA） and rheumatoid factor （RF） were measured in 132 vitiligo patients using electrochemihiminescence analysis, indirect immunofluorescence, and latex agglutination. The positive rates of serum autoantibody were statistically compared between the vitiligo group and the control group. Results The positive rates of TPOAb, TGAb, and RF in vitiligo patients were significantly higher than those in the control group（ P 〈 0. 05 ）, but there was no significant difference in ANA between the vitiligo patients and the healthy volunteers （ P 〉 0.05 ）. Conclusion Some of the autoantibodies in vitiligo patients exceeded the normal level. In view of the vital role of autoimmune in the pathogenesis of vitiligo, measurement of autoantibody levels in vitiligo patients may contribute to the prediction of autoimmune diseases.