聚谷氨酸苄酯/聚乙二醇共聚物的制备与性能研究

Study on the preparation and properties of novel poly(γ-benzyl-L-glutamate)-co-poly(ethylene glycol)

为改善端烯丙基-聚谷氨酸苄酯(A-PBLG)亲水性差和降解速度慢的缺点,采用紫外光交联法将亲水性和抗凝血性能良好的聚乙二醇二甲基丙烯酸酯(DMA-PEG)引入A-PBLG制备出A-PBLG/DMA-PEG共聚物(PBLG-PEG),并对PBLG-PEG的结构和性能进行了研究。结果表明,由于PEG的亲水性和PBLG-PEG中PBLG结晶度的下降导致PBLG-PEG的亲水性和降解性能得到明显的提高。血小板粘附实验和溶血实验研究结果表明PBLG-PEG比A-PBLG具有更好的抗凝血性能。

In order to improve the low biodegradation rate and the poor hydrophility of allyl-terminated poly（γ-benzyl-L-glutamate）（A-PBLG）,dimethylacrylate poly（ethylene glycol）（DMA-PEG） with good hydrophility and antithrombogenicity was introduced to A-PBLG through in situ photo-crosslinking and the copolymer of A-PBLG and DMA-PEG（PBLG-PEG） was obtained.The structure of PBLG-PEG was characterized by Raman and XRD and its water absorbency,in vitro biocompatibility and antithrombogenicity were also studied at the same time.The results indicated that the hydrophility and biodegradation performances of PBLG-PEG were improved because PEG was hydrophilic and crystalline degree of PBLG in PBLG-PEG decreased.The results of blood platelet adhesion and hemolysis experiments showed that PBLG-PEG had better antithrombogenicity than A-PBLG.