药品不良反应信号检测中混杂因素的控制方法

Methods of Controlling Confounding Factors in Adverse Drug Reaction Signal Detection

上市后药品不良反应监测无法实现用药人群的随机化,因此无法控制药品不良反应信号检测中数据的混杂偏倚。通过介绍三种运用较为广泛的混杂因素控制方法,简单分析了各个方法的优缺点和在药品不良反应数据中的应用情况,以期为上市后药品不良反应的准确监测提供借鉴。

It is impossible to randomize the allocation of people using the drug under the post-marketing condition, so hard to control the confounding bias in signal detection of adverse drug reaction（ADR） databases. This article briefly introduces three widely-used methods of controlling confounding bias. It give a brief description of the advantages and limitations of each method, and their applications in ADR signal detection in order to provide some effective information for the post-marketing surveillance.