尿激酶胸腔注射治疗胸膜炎效果观察

Observation of Effect of Intrapleural Injection with Urokinase in Treatment of Tuberculous Pleuritis

目的:探讨尿激酶胸腔内注射防治结核性胸膜炎所致胸膜肥厚粘连的效果。方法:将252例患者随机分为两组,尿激酶组126例,用0.9%氯化钠注射液20 ml加尿激酶5万U于每次抽液后行胸腔内注射;非尿激酶组126例,用0.9%氯化钠注射液20 ml于每次抽液后行胸腔内注射,治疗结束后进行比较。结果:治疗组的胸膜厚度及胸膜粘连发生率明显低于对照组。结论:尿激酶胸腔内注射对结核性胸膜炎所致胸膜肥厚、粘连有一定的防治作用,无明显不良反应,操作简单,值得临床推广应用。

Objective：To investigate the effects of intrapleural injection with urokinase in prevention and treatment of pleural thickening and adhesion due to tuberculous pleuritis. Methods：252 patients with tuberculous pleuritis were divided into two groups by random allocation. Urokinase group：126 cases received intrapleural injection with urokinase 5 × 10^4 U adding into 0.9% sodium chloride injection 20 ml after each thoracic drainage,and non-Urokinase group：126 cases received intrapleural injection with 0.9% sodium chloride injection 20 ml after each thoracic drainage. The effect was compared between the two groups after therapy. Results： The incidence rate was significantly lower in therapeutic group than control group. Conclusions：Intrapleural injection with urokinase has certain prevention and treatment in pleural thickening and adhesion due to tuberculous pleuritis and no obvious adverse reactionin.