复方甘草酸苷治疗抗结核药物性肝炎的临床疗效分析

Clinical analysis of effects of compound glycyrrhizin in the treatment of patients with antituberculosis drug-induced hepatitis

目的观察复方甘草酸苷治疗抗结核药物性肝炎的临床疗效。方法将65例由应用抗结核药物所引起的药物性肝损伤患者随机分为治疗组和对照组,治疗组给予复方甘草酸苷(复方甘草酸苷注射液60 ml加5%葡萄糖注射液250 ml,静脉滴注,每日1次)治疗4周,对照组给予还原型谷胱甘肽(还原型谷胱甘肽1.2 g加入5%葡萄糖注射液250 ml中静脉滴注,每日1次)治疗4周,对两组进行疗效比较。结果治疗组在肝功能恢复,症状、体征的改善方面差异均有显著性(P<0.05)。结论复方甘草酸苷治疗药物性肝炎疗效可靠,值得临床推广。

Objective To observe the efficacy of compound glyeyrrhizin on drug-induced hepatitis by antitubereulosis drugs. Methods Sixty-five patients with drug-induced hepatitis by antituberculosis drugs were randomly assigned to treatment group and control group. The treatment group was treated with compound glycyrrhizin ： compound glycyrrhizin for injection 60 ml and 5% glucose solution 250 ml（ iv gtt,qd）for 4 weeks. The control group was treated with reduetive glutathione： reduetive glutathione 1.2 g and 5% glucose solution 250 ml （ iv gtt, qd） for 4 weeks. The clinical efficacy in the two groups was compared. Results There were significant differences in liver function recovery and in symptoms and signs between the two groups（ P 〈 0. 05 ）. Conlusion Compound glycyrrhizin is effective and reliable on the drug-induced hepatitis. It is worthy of being recommended for a wide use in elinie.