1Sakaguchi S. Naturally arisingFoxp3-expressing CD25^+ CD4^+ regulatory T ceils in immunological tolerance to self and non-self. Nat Immuno,2005,6(4) :345 - 352.
2Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science, 2003, 299 (5609) ..1057 - 1061.
3Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlateswith FoxP3 and suppressive function of human CD4^+ T reg cells. JExp Med,2006,203(7) :1701 - 1711.
4Hartigan-O'Connor DJ,Poon C,Sinclair E,et al. Human CD4^+ regulatory T cells express lower levels of the IL-7 receptor alphaehain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods,2007,319(1-2) :41 -52.
5Annunziato F, Cosmi L, Liotta F, et al. Phenotype, localization, and mechanism of suppression of CD4^+ CD25^+ human thymocytes. J Exp Med,2002 ,196 :379 - 387.
6Ghiringhelli F, Punig PE, Roux S, et al. Tumor cells convert immaturemyeloid dendritic cells into TGF-β-secreting cells inducing CD4^+ CD25^+ regulatory T cell proliferation. J Exp Med ,2005,202 : 919 -929.
7Chu Y, Wang LX, Yang G, et al. Efficacy of GM-CSF-producing tumor vaccine after docetaxel chemotherapy in mice bearingestablished Lewis lung carcinoma. J Immunother, 2006,29 ( 4 ) : 367 - 380.
8Beyer M, Kochanek M, Darabi K, et al. Reduced frequencies and- suppressive function of CD4^ + CD25 hi regulatory T cells in patients- with chronic lymphocytic leukemia after therapy with fludarabine. Blood, 2005,106 ( 6 ) :2018 - 2025.
8Itoh M,Takahashi T,Sakaguchi N,et al.Thymus and autoimmunity:production of CD25^+ CD4^+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.J Immunol,1999; 162:5317 - 5326
9Baecher-Allan C,Brown JA,Freeman GJ,et al.CD4^+ CD25high regulatory cells in human peripheral blood.J Immunol,2001; 167:1245 - 1253
10Sakaguchi S,Sakaguchi N,Asano M,et al.Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alpha-chains(CD25).Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.J Immunol,1995; 155:1151 -1164
