门急诊101例药物不良反应分析

Analysis of 101 ADR Cases in Out-patient and Emergency Department

目的了解门急诊药物不良反应(ADR)的发生特点,促进临床合理用药。方法对101例门急诊静脉治疗药品ADR报告进行回顾性分析。结果101例ADR中,50岁及以上者较多,占总例数的25.74%;与抗感染药物有关的ADR最多见,占总例数的85.15%,其次为循环系统用药和中药制剂等。ADR发生频率最高的3种药品是加替沙星、阿奇霉素和左氧氟沙星。ADR表现以皮肤及其附件的损害最为常见,其次是心血管系统表现和静脉炎。结论临床用药应全面考虑药物不良反应,合理使用各类药物,尽量减少不良反应发生。

Objective The characteristics of adverse drug reaction（ADR） in our out-patient and emergency department was investigated,so as to promote rational drug use in clinic. Methods A total of 101 ADR reports in out-patient and emergency were analyzed retrospectively. Results A- mong the 101 ADR cases, 25. 74% occurred in patients aged 50-year-old and beyond; 85. 15~ ADR cases were associated with anti-infection agents, followed by circulatory system agents and the traditional Chinese traditional medicine etc. The first three drugs that involved in high incidences of ADRs were gatifloxacim, azithromycin, and levofloxacin. The most common clinical manifestations were the damage of skin and adnexa, followed by cardiovascular system damage and phlebitis and etc. Conclusion Great attention shoud be paid to the development of ADR in clinic. Rational use of drugs should be emphasized to decrease the occurrence of ADR.