瓜蒌子降血糖作用及其有效成分初步研究

Studies on the Hypoglycemic Effect of Semen Trichosanthis and Its Effective Constituents

为观察瓜蒌子及其不同组分的降血糖作用，分别给ICR小鼠四氧嘧啶糖尿病模型投食瓜蒌子药材50g/kg、灌胃瓜蒌子提取物石油醚部分16、4g／kg、乙酸乙酯部分1．2、0．3g／kg、正丁醇部分0．4、0．1g／kg，连续4周，每周检测体重、血糖，同时测定各组分单次给药的糖耐量。结果显示瓜蒌子原药材及其石油醚提取部分对四氧嘧啶糖尿病小鼠的血糖升高有一定的抑制作用，并能促进该模型小鼠的体重增长；此外，瓜萎子石油醚提取部分对糖耐量有一定的改善的作用。以上结果提示瓜蒌子具有一定的降血糖作用，其有效成分可能是来自石油醚提取部分。

In order to observe the hypoglycemie effect of Semen Trichosanthis（ST） and its effective fractions,the experiments on alloxan-indueed diabetic mice were studied. The results showed that Semen Trichosanthis can reduce the levels of blood glucose and increase the weight of alloxan-indueed diabetic mice when fed them with 50 g/kg of Semen Trichosanthis, and the petroleum ether extract not only has the same effects, but also can improve the glucose tolerance in alloxan-induced diabetic mice. The result hereinbefore suggested that Semen Trichosanthis may potentiate the hypoglycemic effect, and its effective fractions may come from the petroleum ether extract.