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Nogo受体与脊髓损伤后神经再生的研究进展 被引量：1

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摘要 脊髓损伤(spinal cord injury,SCI)后轴突的再生极差,神经功能难以恢复。研究表明,SCI后髓磷脂相关抑制物是抑制中枢神经轴突再生的关键因素之一。Nogo受体(NgR)是3种髓磷脂相关轴突生长抑制蛋白作用的共同点。本文回顾了NgR及其相关蛋白的结构、功能及相关研究的进展,探讨了作用于NgR的信号机制及以NgR为靶点来提高脊髓损伤后轴突再生疗效的方案。指出以NgR为靶点来促进脊髓损伤后神经功能恢复具有光明的前景,但还需进一步的研究彻底了解NgR及其相关蛋白在抑制轴突再生方面的作用。
作者 田野 张颖 袁文
机构地区 第二军医大学附属长征医院骨科
出处 《中国骨与关节外科》 2009年第6期505-508,共4页 Chinese Journal of Bone and Joint Surgery
关键词 NOGO受体 脊髓损伤 神经再生
分类号 R651.2 [医药卫生—外科学]
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参考文献37

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二级参考文献35

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中国骨与关节外科
2009年 第6期

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