硫酸镁治疗急性脑梗死的临床疗效对比研究

Clinical study of MgSO4 on treatment to acute cerebral infaction

目的评价硫酸镁（MgSO4）治疗急性脑梗死的临床疗效、对脑梗死体积的影响。方法对75例急性脑梗死病例随机分为硫酸镁组、硫酸镁加胰岛素组及对照组。各组均采用血塞通注射液作为基础治疗，硫酸镁和胰岛素分别静脉滴注，1日1次．连用2周。应用神经功能缺失评分评价神经功能情况，利用CT拍片计算梗死灶体积。结果硫酸镁与加胰岛素组明显优于对照组，治疗后梗死灶体积小于对照组。硫酸镁与加胰岛素组间无显著性（P〉0.05）。结论硫酸镁治疗急性脑梗死有效，且安全。硫酸镁与胰岛素无协同作用，

Objective To evaluate the efficacy and safety of MgSO4 treating to acute cerebral infaction. Methods The three groups was all treated with Xuesaitong injection as a basic treatment. MgSO4 and insulin was separately added to the test groups every day for about two weeks. The neurological function was evaluated with the criteria. The volume of the infarct focus was measured on CT. Results The neurological function was recovered significantly better than the controi group at 14 days, and the volume of the infarct focus was significantly less than the control group. There is no significantly difference between the two test groups（P 〉 0.05）. Conclusion MgSO4 is efficient and safe in treatment to acute cerebral infarction. MgSO4 and insulin can not exert their action in coordination.