舒芬太尼、芬太尼术后皮下镇痛治疗对比研究

THE CONTRAST STUDY OF HYPODERMIC ANALGESIA WITH SUFENTANIL AND FENTANIL AFTER SURGICAL OPERATION

目的:对比观察舒芬太尼与芬太尼术后皮下镇痛的效果差异性。方法:90例病人ASA I^III级,17~75岁,随机分为舒芬太尼(S)和芬太尼(F)两组,每组45例。分别用舒芬太尼100ug+利多卡因200mg+地塞米松10mg和芬太尼1mg+利多卡因200mg+地塞米松10mg行皮下自控镇痛,观察术后4、8、20、48小时的镇痛镇静效果、按压次数和有无恶心、呕吐、皮肤搔痒、呼吸抑制等并发症的发生。结果:观察各时间点两组差异均有显著的统计学意义(P<0.01),自控按压次数为F组60次,S组106次,组间各时点按压次数差异无统计学意义(P>0.05)。镇静和恶心、呕吐两组差异无统计学意义(P>0.05)。结论:皮下途径给药,舒芬太尼的镇痛作用优于芬太尼。且操作更简便,安全性更好。

Objective： To compare the efficacy difference between sufentanil and fentanil for patient-controlled hypodermic analgesia after surgical operation.Methods： 90 patients aged 17～75,after surgical operation ASA I-III,35 male,55 female,were randomly divided into two groups： group S（n=45） received sufentanil 100μg ＋ lidocaine 200mg＋dexamethasone 10mg and group F（n=45） received fentanil 1mg＋lidocaine 200mg＋dexamethasone 10mg.Both the two group patients received patient-controlled subcutaneous analgesia after surgical operation.To observe the effect of 4,8,20,48 hours after operation.Results： The analgesic effect of sufentanil was better than that of fentanil and there was significant difference within 4,8,20,48 hours（P〈0.01）.The frequency pressed by patients,the effect of sedation,the rate of nausea and vomiting did not have significant difference（P〉0.05）.Conclusion： Through subcutaneous injection,the analgesic effect of sufentanil is better than that of fentanil as it happened through intravenous and epidural injection.The analgesic method is easier to operate than other methods and also superior to them in safety.