青霉烯类抗生素双环母核合成研究进展

Review on the bicyclonucleus of penems antibiotics synthesis

本文综述了近年来青霉烯类抗生素双环母核的合成进展情况。在各种合成方法中,Wittig环合法逐步发展起来,得到各方面的改进。改进的Wittig环合法在青霉烯双环母核合成中起到重要作用。该方法可以被推广使用。

In recent years, the synthetic routes of the bicyclonucleus of penems have been developed rapidly. Many methods were used, of which Wittig cyclization has been improved. This method become very important. Many bicyclonucleus have been synthesized via this way. Wittig cyclization could be used widely.