盐酸青藤碱对心脏收缩间期的影响与其血药浓度的关系

RELATIONSHIP BETWEEN PLASMA CONCENTRATION OF SINOMENINE HYDROCHLORIE AND ITS EFFECTS ON SYSTOLIC TIME INTERVALS

给家兔静注盐酸青藤碱（SIN）20mg／kg，于给药后6h内不同时间测定心脏收缩间期（STI）并用薄层扫描法测定血药浓度。根据Hill作图法求出药物对STI的延长效应E与血药浓度C的数学关系式为：ELVET＝28·C2.038／（C2.038＋1．52.038）；EQS2＝27·C1.712／（C2.712＋2．41.712）；而EPEP与血药浓度有一定的量效关系但用Hill方程时直线相关不显著。提示SIN对STI中LVET和QS2的延长效应与其血药浓度呈显著的效应-浓度依赖关系。

20mg/kg of Sinomenine hydrochloride (SIN) was injected intravenously into rabbitsand plasma concentration and systolic time intervals(STI) were measured in various time within 6h afteradministration. The relationship between the prologing effects of SIN on STI(E) and its plasma concentration (C ) was calculated with Hill's plottingmethod. The mathemetic relation between SIN plasma concentration and its prologing effects on leftventricular ejection time (LVET) and Q-S2 inteval(QS2) could be respectively expressed as hyperbolaequations: ELVET=28. C2.308/ (C2.308 + 1. 52. 308 ) andEQS2 = 27· C1.712 / (C1.712 + 2. 41.712). In conclussion:There were significant correlations between SINplasma concentration and its prolonging effects onLVET and Q-S2 while no noticeable correlation wasfound for pre-ejection period (PEP) though therewas a concentration-dependent response trend.