多抗甲素对淋巴细胞免疫功能的影响

THE EFFECT OF POLYACTIN A ON THE LYMPHOCYTE IMMUNOFUNCTION

应用3H－TdR及14C－UR参入淋巴细胞的双标记方法，在体外培养条件下，研究多抗甲素对人淋巴细胞DNA及RNA合成功能的影响。结果表明，在多抗甲素的浓度为0．1～10mg／L时，可显著增强淋巴细胞DNA及RNA的合成功能；当多抗甲素的浓度增至50～100mg／L时，对淋巴细胞合成DNA及RNA的能力呈现抑制作用，3H及14C标记物的参入计数减少。多抗甲素对淋巴细胞DNA及RNA合成功能的影响呈现双相作用。

Through the double labeling way of 3H-TdR and 14C-UR adding to the lymphocyte, In vitro culture, was studied the synthetic function of human lymphocyte DNA and RNA. The resultsshowed that when the concentration of polyactin Awas 0. 1 ~ 10μg/ml, was reinforced synthetic function of lypmphocyte DNA and RNA, but when theconcentration polyactin A was added to 50～100μg/ml, the significant depression effect on syntheticfunction of lymphocyte DNA and RNA existed, theparticipant count of the table 3H and 14C was obviously decreased, the effect of polyactin A on thesynthetic function of lymphocyte DNA and RNAwas diphasic.