MG_7-Ag与AgNOR联用鉴别胃癌与癌前病变

STUDY ON THE COMBINATION OF MG_7-Ag WITH AgNOR FOR DISCRIMINATING PRECANCEROUS LESIONS FROM GASTRIC CANCER

用MG7－Ag和AgNOR法对30例胃癌、20例胃粘膜上皮中重度异型增生、31例肠上皮化生及20例正常胃粘膜进行了研究。结果显示胃癌组MG7－Ag强阳性率高于异型增生和肠上皮化生（P＜0.05）。胃癌细胞核内AgNOR形态和计数与良性病变明显不同。以MG7－Ag强阳性表达和细胞核内AgNOR计数明显增多（＞9．12）或大小不等是团块状分布为阳性指标，MG7－Ag和AgNOR联用，胃癌检出率达90％，显著高于单项使用的检出率（P＜0．025）。结果表明，MG7－Ag与AgNOR联用，对区分胃癌与癌前病变具有重要价值。

With combination of MG7-Ag andAgNOR methods, we studied 30 cases of gastriccancer, 20 cases of moderate and severe gastric dysplasia and 31 cases of intestinal metaplasia(IM) and20 cases of normal gastric mucosa. It was foundthat the strong positive rate of MG7-Ag in gastriccancer was significantly higher than that in dysplasiaand that in IM(P <0. 005). Gastric cancer was significantly different from benign lesions in AgNORmorphology and AgNOR numbers. Taking strongpositive reaction and marked increase in AgNORnumbers(>9. 12), variation in granule size and uneven distribution with lump formation as positivecriteria, the detection rate of gastric cancer usingthese parameters of MG7-Ag and AgNOR was90%, being higher than that when either of the twomethods was used (P < 0. 025). The results indicate the combination of MG7-Ag with AgNORmethod may be of high value to discriminating precancerous lesions from gastric cancer.