胃癌中内分泌细胞及其意义

THE ROLE OF ENDOCRINE CELLS IN GASTRIC CARCINOMA

应用免疫组化ABC法对48例胃癌进行胃泌素、生长抑素、胰高血糖素标记。结果胃泌素阳性14例（29．2％），生长抑素阳性9例（18．7％），两者均阳性者6例（12．5％）。未分化腺癌中内分泌细胞阳性率较高分化腺癌高。胃泌素阳性组其浆膜浸润率13／14例（92．9％），淋巴结转移率11／14例（78．5％），明显高于阴性组（P<0.01）。生长抑素阳性组浆膜浸润率6／9例（66．7％），淋巴结转移率4／9例（44．4％），与阴性组相比均无明显差异（P＞0．05），提示胃泌素有促进癌细胞生长的作用，癌细胞生长愈活跃，其侵袭能力愈强，转移率愈高。

Gastrin, somatostatin, glucagon ingastric carcinoma taken from 48 cases were observedby immunohistochemical labeling methods. The results revealed that gastrin in 14 cases was positive(29. 2%), somatostatin in 9 cases was positive(18. 7% ), both gastrin and somatostatin were positive in 6 cases (12. 5% ). The positive rate of endocrine cells in undifferential carcinoma was significantly higher than that of hyperdifferentiatedcarcinoma. Serosa infiltrative rate was 13/14 (92. 9% ) and lymphatic metastases rate was if/14(78. 5% ) in gastrin positive group. The two rateswere prominently higher than those in gastrin negtive group (P < 0. 01 ). In somatostatin positivegroup, serosa infiltrative rate was 6/9 (66. 7 % ) andlymphatic metastases rate was 4/9 (44. 4%), therewas no significant difference compared with those ofsomatostatin negtive group (Tff$465 M)(I&$457 N ) (P >0. 05). The results suggestthat gastrin might accelerate the proliferation ofcarcinoma cells, the more active the carcinomacells, the more strongly invasiving and highermetastases rate. The roles of somatostatin in gastric carcinoma need further investigation.