系统性红斑狼疮患者血清λ1干扰素的测定及临床意义

Serum Levels and Clinical Significance of Interferon-λ1 in Systemic Lupus Erythematosus Patients

目的检测系统性红斑狼疮(SLE)患者血清中λ1干扰素(IFN-λ1)的水平,探讨其水平与SLE其他指标的关系及其在SLE发病中的作用。方法采用ELISA法检测60例SLE患者和20名正常对照者血清IFN-λ1水平,统计分析其与SLE活动指数(SLEDAI)及其他实验室指标的相关性。结果SLE患者血清IFN-λ1水平为(74.2±16.1)pg/ml,其中病情活动组为(75.1±17.3)pg/ml,病情非活动组为(72.5±17.3)pg/ml,均高于正常对照组(70.4±12.6)pg/ml,但差异无统计学意义,且病情活动组高于病情非活动组,差异也无统计学意义。SLE患者中白细胞减少组血清IFN-λ1水平为(80.1±18.1)pg/ml,高于正常对照组,但差异无统计学意义(P=0.052),同时也高于SLE患者中白细胞正常组(70.6±13.7)pg/ml,差异有统计学意义(P=0.024)。血清IFN-λ1与SLEDAI、C3、C4、24h尿蛋白定量等临床指标不相关。结论IFN-λ1可能参与SLE白细胞减少的过程,本研究未证实IFN-λ1水平与疾病活动相关。

Objective To investigate the clinical significance of serum interferon-M （IFN-M） levels in patients with systemic lupus erythematosus （SLE）. Methods ELISA was used to evaluate the serum level of interferon-M in 60 patients with SLE and 20 healthy individuals as normal control. SPSS10.0 statistic software was employed to investigate the relation between the serum IFN-M level,the laboratory index and SLE disease activity index （SLEDAI）. Results The serum IFN-λl level in SLE patients （74.2±16.1 pg/ml） was higher than that of the normal controls （70.4±12.6μg/ml,P =0.339）.The serum IFN-λl level in SLE patients with leucopenia （80.1±18.1 pg/ml） was higher than those of the normal control（P =0.052） and the SLE patients without leucopenia （70.6λl13.7 μg/ml,P =0.024）. The serum IFN-λl level was not correlated with SLEDAI,complements C3,C4,24-hour-proteinuria. Conclusion IFN-λl may be involved in the pathogenesis of leukopenia in SLE and it has not been proved that its level was correlated with the disease activity.