胆固醇结石与肝脏SRBI基因表达关系的探讨

目的探讨胆固醇结石与肝脏SRBI基因表达关系。方法选取20例胆囊胆固醇结石患者和20例健康者作为试验组和对照组,分别测定血清HDL,胆汁总脂,胆汁总脂中各成分含量以及胆汁胆固醇饱和指数。对测量结果进行对比分析。结果实验组患者血清HDL和胆汁总脂显著低于对照组(P<0.05),其它各项测量指标值则均显著高于对照组(P<0.05)。结论肝脏SRBI过表达,可能与胆汁胆固醇过饱和有关,是胆固醇结石病的重要遗传因素。

Objective To study the relationship about cholesterol gallstone and SRBI gene expression. Methods 20 cases of patients with cholesterol gallstone and 20 cases of healthy person were selected respectively for experimental group and control group. Serum HDL, gall total lipids biliary composition and cholesterol saturation index were measured. Results Except Serum HDL and gall total lipids were significantly lower, the other index of experimental group was significantly higher than control group（P0.05）. Conclusion The excessive expression of liver SRBI gene may lead to the excessive saturation of biliary cholesterol. So it is the important hereditary factors of cholesterol gallstone diseases.