子宫非典型性息肉状腺肌瘤合并腺肌瘤2例临床病理分析

目的探讨子宫非典型性息肉状腺肌瘤的临床病理特征。方法复习2例子宫非典型性息肉状腺肌瘤,综合分析。结果2例均为生育期妇女。肿瘤1例位于宫颈管,1例位于宫体。组织学上,不规则腺体呈息肉状增生,细胞具有非典型性,间质可见平滑肌和纤维母细胞增生。其中1例可见典型桑葚状化生。2例均合并息肉下方肌层内腺肌瘤免疫组织化学染色:所有病例间质均显示SMA和Desmin(+),腺体显示ER和PR(+),p53(-),Ki-67增生指<10%。2例均行子宫切除术。结论子宫非典型性息肉状腺肌瘤具有特征性组织结构:即在平滑肌纤维间质中出现复杂增生的腺体。典型的病例临床过程良好,部分病例具有低度恶性潜能,病变可复发,需长期随访。

Objective To explore the clinicopathological features of the atypical polypoid adenomyoma （APA） of the uterus. Methods Clinical data was performed in 2 cases of APA, with follow-up in 2 cases. Results Two patients were premenopausal, one in cervical canal, and one at the uterine fundus. Histologically, the lesions featured a polypoid proliferation of iffegular, atypical endometrial glands, with a smooth-muscle and fibroblastic stroma. Conclusions Atypical polypoid adenomyoma has histological features of proliferation of architecturally complex and cytological atypical glands within a smooth-muscle fiber stroma.